Review
doi: 10.1016/s0092-8674(00)00117-3.
TOR, a central controller of cell growth
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- PMID: 11057898
- DOI: 10.1016/s0092-8674(00)00117-3
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Review
TOR, a central controller of cell growth
Cell.
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Free article
Abstract
Cell growth (increase in cell mass) and cell proliferation (increase in cell number) are distinct yet coupled processes that go hand-in-hand to give rise to an organ, organism, or tumor. Cyclin-dependent kinase(s) is the central regulator of cell proliferation. Is there an equivalent regulator for cell growth? Recent findings reveal that the target of rapamycin TOR controls an unusually abundant and diverse set of readouts all of which are important for cell growth, suggesting that this conserved kinase is such a central regulator.
Comment in
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Signaling networks: the origins of cellular multitasking.Cell. 2000 Oct 13;103(2):193-200. doi: 10.1016/s0092-8674(00)00112-4. Cell. 2000. PMID: 11057893 Free PMC article. Review. No abstract available.
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