Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Randomized Controlled Trial
. 2014 Apr;252(4):619-26.
doi: 10.1007/s00417-014-2599-1. Epub 2014 Feb 25.

The efficacy of autologous serum eye drops for severe dry eye syndrome: a randomized double-blind crossover study

Ali Riza Cenk Celebi  1 , Cemalettin Ulusoy, G Ertugrul Mirza
Affiliations
Randomized Controlled Trial

The efficacy of autologous serum eye drops for severe dry eye syndrome: a randomized double-blind crossover study

Ali Riza Cenk Celebi et al. Graefes Arch Clin Exp Ophthalmol. 2014 Apr.

Abstract

Background: To evaluate the efficacy of autologous serum (AS) eye drops for the symptomatic relief of severe dry eye syndrome (DES), as compared to conventional preservative-free artificial tears (PFAT).

Methods: This prospective double-blind randomized crossover study used the Ocular Surface Disease Index (OSDI), tear film break-up time (TBUT), Schirmer's Test, and OXFORD Scale at baseline and after each of two 1-month treatment periods to measure the effect of 20 % diluted AS eye drops vs. PFAT in 20 consecutive severe DES patients that were refractory to conventional treatment.

Results: The study included 20 (18 female and two male) severe DES patients (40 eyes). Significantly higher TBUT (P < 0.001, Wilcoxon signed-rank test) and a greater decrease in OSDI score (55.18 % decrease in the AS treatment group vs. 19.50 % decrease in the PFAT treatment group) (P < 0.001, Student's paired samples t-test) were observed in the AS treatment group after 1 month of treatment. There wasn't a significant difference in Schirmer's test and OXFORD conjunctival and corneal vital dying grading scores between the two treatment groups after 1 month of treatment (P > 0.05 [Mann-Whitney U test]).

Conclusions: AS eye drops were more effective than conventional eye drops for improving tear film stability and subjective comfort in patients with severe DES.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Br J Ophthalmol. 1999 Apr;83(4):390-5 - PubMed
    1. Am J Ophthalmol. 2003 Aug;136(2):291-9 - PubMed
    1. Clin Exp Ophthalmol. 2008 Mar;36(2):119-22 - PubMed
    1. Ophthalmology. 2004 Jun;111(6):1115-20 - PubMed
    1. Arch Ophthalmol. 1988 Oct;106(10):1423-5 - PubMed

Publication types

LinkOut - more resources