Merkel cell carcinoma: analysis of clinical, histologic, and immunohistologic features of 132 cases with relation to survival
- PMID: 9366819
- DOI: 10.1016/s0190-9622(97)70110-5
Merkel cell carcinoma: analysis of clinical, histologic, and immunohistologic features of 132 cases with relation to survival
Abstract
Background: Merkel cell carcinoma (MCC) is an uncommon malignancy of the skin and has a high rate of recurrence and metastasis. There have been few large studies of the biologic behavior of MCC.
Objective: Our purpose was to determine whether there were clinical or histologic features of MCC that predict its biologic behavior.
Methods: We reviewed 132 cases of MCC. Clinical and histologic features were correlated with follow-up information to determine whether any of these were associated with prognosis.
Results: Clinical information was available on 126 patients; 57 were alive, 1 was alive with tumor, 28 died of tumor, 27 died from other causes, and 14 were lost to follow-up. MCC on the buttock/thigh area or trunk had the worst prognosis, and those on the distal extremities had the best prognosis; however, the difference was not statistically significant. Sex and age were not significant factors. Small cell size, high mitotic rate, and large tumor size were associated with a low survival rate. When cell size was excluded, male sex and depth of invasion were associated with a worse survival, although these were not statistically significant.
Conclusion: Cell size, mitotic rate, and tumor size are significant factors in relation to the biologic behavior of MCC.
Similar articles
-
Differentiation between merkel cell carcinoma and malignant melanoma: An immunohistochemical study.Dermatology. 2000;201(2):123-6. doi: 10.1159/000018454. Dermatology. 2000. PMID: 11053914
-
Merkel cell carcinoma: a clinicopathologic study with prognostic implications.J Cutan Pathol. 2004 Mar;31(3):217-23. doi: 10.1111/j.0303-6987.2004.00149.x. J Cutan Pathol. 2004. PMID: 14984573
-
Merkel cell carcinoma: does tumor size or depth of invasion correlate with recurrence, metastasis, or patient survival?Laryngoscope. 2006 May;116(5):791-5. doi: 10.1097/01.mlg.0000208615.93883.b2. Laryngoscope. 2006. PMID: 16652089
-
Merkel cell carcinoma: report of 10 cases and review of the literature.J Am Acad Dermatol. 2000 Nov;43(5 Pt 1):755-67. doi: 10.1067/mjd.2000.106505. J Am Acad Dermatol. 2000. PMID: 11050578 Review.
-
Merkel cell carcinoma of the tongue and head and neck oral mucosal sites.Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006 Jun;101(6):761-8. doi: 10.1016/j.tripleo.2005.10.068. Epub 2006 Mar 20. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006. PMID: 16731397 Review.
Cited by
-
Diagnostic confusion resulting from CD56 expression by cutaneous myeloid sarcoma.Rare Tumors. 2009 Dec 28;1(2):e51. doi: 10.4081/rt.2009.e51. Rare Tumors. 2009. PMID: 21139930 Free PMC article.
-
Cutaneous metastasis from pulmonary large cell neuroendocrine carcinoma in the scalp.Int J Clin Exp Pathol. 2014 Apr 15;7(5):2701-6. eCollection 2014. Int J Clin Exp Pathol. 2014. PMID: 24966991 Free PMC article. No abstract available.
-
Merkel Cell Carcinoma.Surg Pathol Clin. 2017 Jun;10(2):399-408. doi: 10.1016/j.path.2017.01.013. Epub 2017 Mar 14. Surg Pathol Clin. 2017. PMID: 28477888 Free PMC article. Review.
-
Merkel Cell Carcinoma and Diagnostic Experience in a Reference Hospital: A Case Series.Case Rep Med. 2020 Feb 19;2020:8391510. doi: 10.1155/2020/8391510. eCollection 2020. Case Rep Med. 2020. PMID: 32148513 Free PMC article.
-
Mutational analysis of merkel cell carcinoma.Cancers (Basel). 2014 Oct 17;6(4):2116-36. doi: 10.3390/cancers6042116. Cancers (Basel). 2014. PMID: 25329450 Free PMC article. Review.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
