Neuropsychiatric symptoms in spinocerebellar ataxias and Friedreich ataxia
- PMID: 37137435
- DOI: 10.1016/j.neubiorev.2023.105205
Neuropsychiatric symptoms in spinocerebellar ataxias and Friedreich ataxia
Abstract
Apart from its role in motor coordination, the importance of the cerebellum in cognitive and affective processes has been recognized in the past few decades. Spinocerebellar ataxias (SCA) and Friedreich ataxia (FRDA) are rare neurodegenerative diseases of the cerebellum presenting mainly with a progressive loss of gait and limb coordination, dysarthria, and other motor disturbances, but also a range of cognitive and neuropsychiatric symptoms. This narrative review summarizes the current knowledge on neuropsychiatric impairment in SCA and FRDA. We discuss the prevalence, clinical features and treatment approaches in the most commonly reported domains of depression, anxiety, apathy, agitation and impulse dyscontrol, and psychosis. Since these symptoms have a considerable impact on patients' quality of life, we argue that further research is mandated to improve the detection and treatment options of neuropsychiatric co-morbidities in ataxia patients.
Keywords: Agitation; Anxiety; Apathy; Depression; Friedreich ataxia; Neuropsychiatric symptoms; Psychosis; Spinocerebellar ataxia.
Copyright © 2023 The Authors. Published by Elsevier Ltd.. All rights reserved.
Conflict of interest statement
Declaration of Competing Interest None.
Similar articles
-
Exploring neuropsychiatric symptoms in Friedreich ataxia.Sci Rep. 2024 Nov 23;14(1):29076. doi: 10.1038/s41598-024-80258-9. Sci Rep. 2024. PMID: 39580547 Free PMC article.
-
Friedreich and dominant ataxias: quantitative differences in cerebellar dysfunction measurements.J Neurol Neurosurg Psychiatry. 2018 Jun;89(6):559-565. doi: 10.1136/jnnp-2017-316964. Epub 2017 Dec 26. J Neurol Neurosurg Psychiatry. 2018. PMID: 29279305
-
Cognitive, Emotional, and Other Non-motor Symptoms of Spinocerebellar Ataxias.Curr Neurol Neurosci Rep. 2024 Mar;24(3):47-54. doi: 10.1007/s11910-024-01331-4. Epub 2024 Jan 25. Curr Neurol Neurosci Rep. 2024. PMID: 38270820 Free PMC article. Review.
-
Comparing speech characteristics in spinocerebellar ataxias type 3 and type 6 with Friedreich ataxia.J Neurol. 2015 Jan;262(1):21-6. doi: 10.1007/s00415-014-7511-8. Epub 2014 Sep 30. J Neurol. 2015. PMID: 25267338
-
Spinocerebellar ataxia type 23 (SCA23): a review.J Neurol. 2021 Dec;268(12):4630-4645. doi: 10.1007/s00415-020-10297-5. Epub 2020 Nov 11. J Neurol. 2021. PMID: 33175256 Review.
Cited by
-
Anxiety in oncology outpatients is associated with perturbations in pathways identified in anxiety focused network pharmacology research.Support Care Cancer. 2023 Nov 28;31(12):727. doi: 10.1007/s00520-023-08196-2. Support Care Cancer. 2023. PMID: 38012456 Free PMC article.
-
Selection of Clinical Outcome Assessments for Trial Readiness in ARSACS - 2-year Progression and Responsiveness to Change Part 2: Mobility, Balance, and Lower Limb Coordination.Cerebellum. 2025 May 7;24(4):95. doi: 10.1007/s12311-025-01849-4. Cerebellum. 2025. PMID: 40332679
-
The analysis of schizophrenia-like psychosis in dentatorubral-pallidoluysian atrophy.Front Neurol. 2025 Apr 9;16:1564856. doi: 10.3389/fneur.2025.1564856. eCollection 2025. Front Neurol. 2025. PMID: 40271115 Free PMC article.
-
Cerebellar microglia: On the edge between neuroinflammation and neuroregulation.Neural Regen Res. 2026 Jan 1;21(1):156-172. doi: 10.4103/NRR.NRR-D-24-00550. Epub 2024 Oct 22. Neural Regen Res. 2026. PMID: 40489344 Free PMC article.
-
Exploring neuropsychiatric symptoms in Friedreich ataxia.Sci Rep. 2024 Nov 23;14(1):29076. doi: 10.1038/s41598-024-80258-9. Sci Rep. 2024. PMID: 39580547 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Medical
Miscellaneous