U.S. flag

An official website of the United States government

NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.

Cover of Charting a Path Toward New Treatments for Lyme Infection-Associated Chronic Illnesses

Charting a Path Toward New Treatments for Lyme Infection-Associated Chronic Illnesses

; Editors: Andrew March, Julie Liao, and Kent Kester.

Washington (DC): National Academies Press (US); .
ISBN-13: 978-0-309-73098-3ISBN-10: 0-309-73098-8

Around 10-20% of people who contract Lyme disease, the most common tickborne disease in the U.S., develop persistent, often debilitating symptoms such as chronic pain, fatigue, and cognitive dysfunction. Lyme infection-associated chronic illnesses (IACI) share symptoms common to other IACI such as Long COVID and myalgic encephalomyelitis/chronic fatigue syndrome. Despite the chronic impact on the quality of life for many people, there are currently no validated interventions to treat Lyme IACI.

In response to this unmet need, the Steven & Alexandra Cohen Foundation asked the National Academies to convene a committee of experts to assess the evidence for disease mechanisms, diagnoses, and treatments of Lyme IACI and illuminate a pathway for the development of new treatments. The resulting report, Charting a Path Toward New Treatments for Lyme Infection-Associated Chronic Illnesses, makes recommendations around developing treatments that improve function and quality of life based on currently available evidence, while continuing research to identify root causes and mechanisms of the disease.

Contents

This activity was supported by contracts between the National Academy of Sciences and the Steven & Alexandra Cohen Foundation. Any opinions, findings, conclusions, or recommendations expressed in this publication do not necessarily reflect the views of any organization or agency that provided support for the project.

Suggested citation:

National Academies of Sciences, Engineering, and Medicine. 2025. Charting a path toward new treatments for Lyme infection-associated chronic illnesses. Washington, DC: National Academies Press. https://doi.org/10.17226/28578.

Digital Object Identifier: https://doi.org/10.17226/28578

Library of Congress Control Number: 2025938379

This publication is available from the National Academies Press, 500 Fifth Street, NW, Keck 360, Washington, DC 20001; (800) 624-6242; http://www.nap.edu.

The manufacturer's authorized representative in the European Union for product safety is Authorised Rep Compliance Ltd., Ground Floor, 71 Lower Baggot Street, Dublin D02 P593 Ireland; www.arccompliance.com.

Printed in the United States of America.

Created: May 8, 2025; Last Update: June 26, 2025.

Copyright 2025 by the National Academy of Sciences. National Academies of Sciences, Engineering, and Medicine and National Academies Press and the graphical logos for each are all trademarks of the National Academy of Sciences. All rights reserved.
Bookshelf ID: NBK616250PMID: 40674535DOI: 10.17226/28578

Views

  • PubReader
  • Print View
  • Cite this Page
  • PDF version of this title (2.7M)

Recent Activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...