The role of pro-inflammatory cytokines in cancer treatment-induced alimentary tract mucositis: pathobiology, animal models and cytotoxic drugs
- PMID: 17507164
- DOI: 10.1016/j.ctrv.2007.03.001
The role of pro-inflammatory cytokines in cancer treatment-induced alimentary tract mucositis: pathobiology, animal models and cytotoxic drugs
Abstract
Alimentary tract (AT) mucositis can be a major problem for patients undergoing cancer treatment. It has significant clinical and economic consequences and is a major factor that can compromise the provision of optimal treatment for patients. The pathobiology of AT mucositis is complex and the exact mechanisms that underlie its development still need to be fully elucidated. Current opinion considers that there is a prominent interplay between all of the compartments of the mucosa involving, at a molecular level, the activation of transcription factors, particularly nuclear factor-kappaB, and the subsequent upregulation of pro-inflammatory cytokines and inflammatory mediators. The purpose of this review is to examine the literature relating to what is currently known about the pathobiology of AT mucositis, particularly with respect to the involvement of pro-inflammatory cytokines, as well as currently used animal models and the role of specific cytotoxic chemotherapy agents in the development of AT mucositis.
Similar articles
-
Is the pathobiology of chemotherapy-induced alimentary tract mucositis influenced by the type of mucotoxic drug administered?Cancer Chemother Pharmacol. 2009 Jan;63(2):239-51. doi: 10.1007/s00280-008-0732-8. Epub 2008 Mar 20. Cancer Chemother Pharmacol. 2009. PMID: 18351341
-
Matrix metalloproteinases: key regulators in the pathogenesis of chemotherapy-induced mucositis?Cancer Chemother Pharmacol. 2009 Jun;64(1):1-9. doi: 10.1007/s00280-009-0984-y. Epub 2009 Mar 21. Cancer Chemother Pharmacol. 2009. PMID: 19305997 Review.
-
Role of interleukin-1beta and tumor necrosis factor-alpha-dependent expression of cyclooxygenase-2 mRNA in thermal hyperalgesia induced by chronic inflammation in mice.Neuroscience. 2008 Mar 18;152(2):477-86. doi: 10.1016/j.neuroscience.2007.10.039. Epub 2007 Nov 12. Neuroscience. 2008. PMID: 18262365
-
Modulation of inflammatory cytokines by omega-3 fatty acids.Subcell Biochem. 2008;49:133-43. doi: 10.1007/978-1-4020-8831-5_5. Subcell Biochem. 2008. PMID: 18751910 Review.
-
Characterisation of mucosal changes in the alimentary tract following administration of irinotecan: implications for the pathobiology of mucositis.Cancer Chemother Pharmacol. 2008 Jun;62(1):33-41. doi: 10.1007/s00280-007-0570-0. Epub 2007 Aug 17. Cancer Chemother Pharmacol. 2008. PMID: 17703303
Cited by
-
The Antiemetic Mechanisms of Gingerols against Chemotherapy-Induced Nausea and Vomiting.Evid Based Complement Alternat Med. 2022 Feb 24;2022:1753430. doi: 10.1155/2022/1753430. eCollection 2022. Evid Based Complement Alternat Med. 2022. PMID: 35251202 Free PMC article. Review.
-
Association of HSV reactivation and pro-inflammatory cytokine levels with the severity of stomatitis after BEAM chemotherapy and autologous SCT.Support Care Cancer. 2011 Aug;19(8):1211-6. doi: 10.1007/s00520-010-0940-8. Epub 2010 Jul 11. Support Care Cancer. 2011. PMID: 20623145
-
Preliminary study on XAGE-1b gene and its mechanism for promoting tumor cell growth.Biomed Rep. 2013 Jul;1(4):567-572. doi: 10.3892/br.2013.122. Epub 2013 May 30. Biomed Rep. 2013. PMID: 24648988 Free PMC article.
-
Mucosal Injury during Anti-Cancer Treatment: From Pathobiology to Bedside.Cancers (Basel). 2019 Jun 20;11(6):857. doi: 10.3390/cancers11060857. Cancers (Basel). 2019. PMID: 31226812 Free PMC article. Review.
-
Host impairments in patients with neoplastic diseases.Cancer Treat Res. 2014;161:1-41. doi: 10.1007/978-3-319-04220-6_1. Cancer Treat Res. 2014. PMID: 24706220 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
