Jasper's Basic Mechanisms of the Epilepsies [Internet]
- PMID: 22787592
- Bookshelf ID: NBK50785
Jasper's Basic Mechanisms of the Epilepsies [Internet]
Excerpt
In 1969, H.H. Jasper, A.A. Ward, and A. Pope and the Public Health Service Advisory Committee on the Epilepsies of the National Institutes of Health published the first edition of Basic Mechanisms of the Epilepsies. The book was developed following a workshop held in Colorado Springs and an open symposium. Since then, basic and clinical researchers in epilepsy have gathered together about every 14 years to assess where epilepsy research has been, what it has accomplished, and where it should go. Each time a book was published. In a foreword written for the second edition of Basic Mechanisms of the Epilepsies, published in 1983, Jasper reminded us that the original and ultimate goal of the Public Health Service committee was to search for a “better understanding of the epilepsies and seek more rational methods of their prevention and treatment.” In 1999, the third edition was named in honor of H.H. Jasper. This fourth edition of Jasper’s Basic Mechanisms of the Epilepsies is based on a series of workshops held for four days at Yosemite National Park in March 2009. The book (1) synthesizes the role of interactions between neurons, synapses, and glia in the initiation, spread, and arrest of seizures; (2) examines the molecular, cellular, and network plasticity mechanisms that subserve excitability, seizure susceptibility, and ultimately epileptogenesis; (3) provides a framework for expanding the genome of rare Mendelian epilepsies and understanding the complex heredity responsible for common epilepsies; (4) explores cellular mechanisms of the two main groups of presently known Mendelian epilepsy genes, the ion channelopathies and developmental epilepsy genes; and (5) for the first time in the Jasper’s series describes the current efforts to translate the discoveries in epilepsy disease mechanisms into new therapeutic strategies. The editors were assisted in reviewing the chapters by an editorial advisory board consisting of Giuseppe Biagini, Amy Brooks-Kayal, Wolfgang Löscher, Helen Scharfman, Phil Schwartzkroin, John Swann, and Annamaria Vezzani.
Copyright © 2012, Michael A Rogawski, Antonio V Delgado-Escueta, Jeffrey L Noebels, Massimo Avoli and Richard W Olsen.
Sections
- Introduction
-
Fundamentals of Neuronal Excitablility Relevant to Seizures and Epilepsy
- Voltage-Gated Na+ Channels: Structure, Function, and Pathophysiology
- Potassium Channels (including KCNQ) and Epilepsy
- Voltage-Gated Calcium Channels in Epilepsy
- Hyperpolarization-Activated Cyclic Nucleotide-Gated (HCN) Ion Channelopathy in Epilepsy
- Phasic GABAA-Mediated Inhibition
- Tonic GABAA Receptor-Mediated Signaling in Epilepsy
- Glutamatergic Mechanisms Related to Epilepsy: Ionotropic Receptors
- Glutamate Receptors in Epilepsy: Group I mGluR-Mediated Epileptogenesis
- Plasticity of Glutamate Synaptic Mechanisms
- Neuronal Synchronization and Thalamocortical Rhythms in Sleep, Wake and Epilepsy
- Limbic Network Synchronization and Temporal Lobe Epilepsy
- Imaging of Hippocampal Circuits in Epilepsy
- Normal and Pathologic High-Frequency Oscillations
- Interictal Epileptiform Discharges in Partial Epilepsy: Complex Neurobiological Mechanisms Based on Experimental and Clinical Evidence
- GABA-A Receptor Function in Typical Absence Seizures
- GABAB Receptor and Absence Epilepsy
- Brainstem Networks: Reticulo-Cortical Synchronization in Generalized Convulsive Seizures
- On the Basic Mechanisms of Infantile Spasms
- Fast Oscillations and Synchronization Examined with In Vitro Models of Epileptogenesis
- Computer Modeling of Epilepsy
-
Mechanisms of Seizure Susceptibility and Epileptogenesis
- Traumatic Brain Injury and Posttraumatic Epilepsy
- Head Trauma and Epilepsy
- Fever, febrile seizures and epileptogenesis
- Role of Blood-Brain Barrier Dysfunction in Epileptogenesis
- Cell death and survival mechanisms after single and repeated brief seizures
- Programmed Necrosis After Status Epilepticus
- Histopathology of Human Epilepsy
- The Time Course and Circuit Mechanisms of Acquired Epileptogenesis
- Mossy Fiber Sprouting in the Dentate Gyrus
- Kainate and Temporal Lobe Epilepsies: 3 decades of progress
- Abnormal dentate gyrus network circuitry in temporal lobe epilepsy
- Alterations in synaptic function in epilepsy
- Seizure-induced formation of basal dendrites on granule cells of the rodent dentate gyrus
- Perturbations of Dendritic Excitability in Epilepsy
- Neurogenesis and Epilepsy
- Temporal Lobe Epilepsy and the BDNF Receptor, TrkB
- Alterations in the Distribution of GABAA Receptors in Epilepsy
- GABAA Receptor Plasticity During Status Epilepticus
- Plasticity of GABAA receptors relevant to neurosteroid actions
- GABAA Receptor Plasticity in Alcohol Withdrawal
- Regulation of GABAA Receptor Gene Expression and Epilepsy
- Chloride homeostasis and GABA signaling in temporal lobe epilepsy
- Astrocytes and Epilepsy
- Astrocyte dysfunction in epilepsy
- Glia-neuronal interactions in ictogenesis and epileptogenesis: role of inflammatory mediators
- Glia-Neuron Interactions: Neurosteroids and Epileptogenesis
-
Epilepsy Genes and Brain Development
- Genetic Epidemiology and Gene Discovery in Epilepsy
- Strategies for Studying the Epilepsy Genome
- Sodium Channel Mutations and Epilepsy
- Potassium Channelopathies of Epilepsy
- The Voltage-Gated Calcium Channel and Absence Epilepsy
- Mutated GABAA receptor subunits in idiopathic generalized epilepsy
- The GABAAγ2(R43Q) mouse model of human genetic epilepsy
- GABAA Receptor Subunit Mutations and Genetic Epilepsies
- Nicotinic acetylcholine receptor mutations
- Gene Interactions and Modifiers in Epilepsy
- Rare genetic causes of lissencephaly may implicate microtubule-based transport in the pathogenesis of cortical dysplasias
- The Generation of Cortical Interneurons
- Genes in infantile epileptic encephalopathies
- Developing Models of Aristaless-related homeobox mutations
-
Haploinsufficiency of
STXBP1 and Ohtahara syndrome - mTOR and Epileptogenesis in Developmental Brain Malformations
- Major Susceptibility Genes for Common Idiopathic Epilepsies: ELP4 in Rolandic Epilepsy and BRD2 in Juvenile Myoclonic Epilepsy
- Myoclonin1/EFHC1 in cell division, neuroblast migration, synapse/dendrite formation in juvenile myoclonic epilepsy
- Progressive myoclonus epilepsy of Lafora
- Progressive myoclonus epilepsy: Unverricht-Lundborg disease and Neuronal ceroid lipofuscinoses
-
GABRB3 , Epilepsy, and Neurodevelopment - Pathophysiology of Epilepsy in Autism Spectrum Disorders
- Cognitive and Behavioral Co-Morbidities of Epilepsy
- Migraine and Epilepsy—Shared Mechanisms within the Family of Episodic Disorders
- Neurobiology of Depression as a Comorbidity of Epilepsy
-
Epilepsy Therapeutics
- Calcium channel α2δ subunits in epilepsy and as targets for antiepileptic drugs
- Targeting SV2A for Discovery of Antiepileptic Drugs
- Neurosteroids — Endogenous Regulators of Seizure Susceptibility and Role in the Treatment of Epilepsy
- Mechanisms of Ketogenic Diet Action
- Deep Brain Stimulation for Epilepsy: Animal Models
- Animal Models for Evaluating Antiepileptogenesis
- Strategies for antiepileptogenesis: Antiepileptic drugs versus novel approaches evaluated in post-status epilepticus models of temporal lobe epilepsy
- Neonatal Seizures and Neuronal Transmembrane Ion Transport
- Antiepileptogenesis, Plasticity of AED Targets, Drug resistance, and Targeting the Immature Brain
- Drug Resistance
- Neural Stem Cell Therapy for Temporal Lobe Epilepsy
- Embryonic Stem Cell Therapy for Intractable Epilepsy
- Cell Therapy Using GABAergic Neural Progenitors
- Reversing Disorders of Neuronal Migration and Differentiation in Animal Models
- Gene therapy of focal onset epilepsy using adeno-associated virus vector-mediated overexpression of neuropeptide Y
- Adenosine Augmentation Therapy
Similar articles
-
"Jasper's Basic Mechanisms of the Epilepsies" Workshop.Epilepsia. 2010 Dec;51 Suppl 5(0 5):1-5. doi: 10.1111/j.1528-1167.2010.02792.x. Epilepsia. 2010. PMID: 21208201 Free PMC article.
-
Herbert H. Jasper and the Basic Mechanisms of the Epilepsies.In: Noebels JL, Avoli M, Rogawski MA, Olsen RW, Delgado-Escueta AV, editors. Jasper's Basic Mechanisms of the Epilepsies [Internet]. 4th edition. Bethesda (MD): National Center for Biotechnology Information (US); 2012. In: Noebels JL, Avoli M, Rogawski MA, Olsen RW, Delgado-Escueta AV, editors. Jasper's Basic Mechanisms of the Epilepsies [Internet]. 4th edition. Bethesda (MD): National Center for Biotechnology Information (US); 2012. PMID: 22787666 Free Books & Documents. Review.
-
Abstracts of Jasper’s Basic Mechanisms of the Epilepsies Workshop. March 23-27, 2009. Yosemite National Park, California, USA.Epilepsia. 2010 Dec;51 Suppl 5:1-97. Epilepsia. 2010. PMID: 21268788 No abstract available.
-
New wave of research in the epilepsies.Adv Neurol. 1986;44:3-55. Adv Neurol. 1986. PMID: 2871720 Review.
-
Neurobiology of Depression as a Comorbidity of Epilepsy.Epilepsia. 2010 Dec;51(s5):81. doi: 10.1111/j.1528-1167.2010.02867.x. Epilepsia. 2010. PMID: 21415938 Free PMC article.
Publication types
LinkOut - more resources
Full Text Sources