Priming for health: gut microbiota acquired in early life regulates physiology, brain and behaviour
- PMID: 24798884
- DOI: 10.1111/apa.12674
Priming for health: gut microbiota acquired in early life regulates physiology, brain and behaviour
Abstract
The infant gut microbiome is dynamic, and radical shifts in composition occur during the first 3 years of life. Disruption of these developmental patterns, and the impact of the microbial composition of our gut on brain and behaviour, has attracted much recent attention. Integrating these observations is an important new research frontier.
Conclusion: Early-life perturbations of the developing gut microbiota can impact on the central nervous system and potentially lead to adverse mental health outcomes.
Keywords: Behaviour; Brain Development; Breastfeeding; Early Life; Microbiota.
©2014 Foundation Acta Paediatrica. Published by John Wiley & Sons Ltd.
Similar articles
-
Microbiota and neurodevelopmental windows: implications for brain disorders.Trends Mol Med. 2014 Sep;20(9):509-18. doi: 10.1016/j.molmed.2014.05.002. Epub 2014 Jun 20. Trends Mol Med. 2014. PMID: 24956966 Review.
-
Gut/brain axis and the microbiota.J Clin Invest. 2015 Mar 2;125(3):926-38. doi: 10.1172/JCI76304. Epub 2015 Feb 17. J Clin Invest. 2015. PMID: 25689247 Free PMC article. Review.
-
Reduced anxiety-like behavior and central neurochemical change in germ-free mice.Neurogastroenterol Motil. 2011 Mar;23(3):255-64, e119. doi: 10.1111/j.1365-2982.2010.01620.x. Epub 2010 Nov 5. Neurogastroenterol Motil. 2011. PMID: 21054680
-
Gut Microbiota-brain Axis.Chin Med J (Engl). 2016 Oct 5;129(19):2373-80. doi: 10.4103/0366-6999.190667. Chin Med J (Engl). 2016. PMID: 27647198 Free PMC article. Review.
-
Gut-brain axis: how the microbiome influences anxiety and depression.Trends Neurosci. 2013 May;36(5):305-12. doi: 10.1016/j.tins.2013.01.005. Epub 2013 Feb 4. Trends Neurosci. 2013. PMID: 23384445 Review.
Cited by
-
Cortisol in Neonatal Mother's Milk Predicts Later Infant Social and Cognitive Functioning in Rhesus Monkeys.Child Dev. 2018 Mar;89(2):525-538. doi: 10.1111/cdev.12783. Epub 2017 Mar 29. Child Dev. 2018. PMID: 28369689 Free PMC article.
-
Early life microbiome disbalance impacts neuroendocrine outcomes in pre-pubertal mice in a sexually dimorphic manner.Front Microbiol. 2025 Jun 20;16:1504513. doi: 10.3389/fmicb.2025.1504513. eCollection 2025. Front Microbiol. 2025. PMID: 40693139 Free PMC article.
-
Evolutionary Significance of the Neuroendocrine Stress Axis on Vertebrate Immunity and the Influence of the Microbiome on Early-Life Stress Regulation and Health Outcomes.Front Microbiol. 2021 Apr 7;12:634539. doi: 10.3389/fmicb.2021.634539. eCollection 2021. Front Microbiol. 2021. PMID: 33897639 Free PMC article. Review.
-
Protocol for the Emory University African American maternal stress and infant gut microbiome cohort study.BMC Pediatr. 2019 Jul 22;19(1):246. doi: 10.1186/s12887-019-1630-4. BMC Pediatr. 2019. PMID: 31331308 Free PMC article.
-
Photoperiod modulates the gut microbiome and aggressive behavior in Siberian hamsters.J Exp Biol. 2020 Jan 31;223(Pt 3):jeb212548. doi: 10.1242/jeb.212548. J Exp Biol. 2020. PMID: 31862850 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
