Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1993 Jun;84(6):697-702.
doi: 10.1111/j.1349-7006.1993.tb02031.x.

Relationship between development of diarrhea and the concentration of SN-38, an active metabolite of CPT-11, in the intestine and the blood plasma of athymic mice following intraperitoneal administration of CPT-11

E Araki  1 , M Ishikawa, M Iigo, T Koide, M Itabashi, A Hoshi
Affiliations

Relationship between development of diarrhea and the concentration of SN-38, an active metabolite of CPT-11, in the intestine and the blood plasma of athymic mice following intraperitoneal administration of CPT-11

E Araki et al. Jpn J Cancer Res. 1993 Jun.

Abstract

Severe diarrhea occurred during daily intraperitoneal administration of 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin (CPT-11) at a dose of 50 mg/kg in athymic mouse. Serial determination of CPT-11 and 7-ethyl-10-hydroxycamptothecin (SN-38), with the use of an on-line solid extraction HPLC system, demonstrated that much higher levels of the compounds are retained in the intestine and the blood plasma after five consecutive daily injections than after a single injection. Histologic examination of the gastrointestinal tract showed hemorrhagic colitis on day 7 and later after five consecutive daily injections of CPT-11. The direct cause of diarrhea associated with CPT-11 administration is considered to be enterocolitis caused by high levels of SN-38 and/or CPT-11 retained for a long period in the intestine.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. ) Kunimoto , T. , Nitta , K. , Tanaka , T. , Uehara , N. , Baba , H. , Takeuchi , M. , Yokokura , T. , Sawada , S. , Miyasaka , T. and Mutai , M.Antitumor activity of 7‐ethyl‐10‐[4‐(1 ‐piperidino) ‐1 ‐piperidino] carbonyloxycamptothecin, a novel water‐soluble derivative of camptothecin, against murine tumors . Cancer Res. , 47 , 5944 – 5947 ( 1987. ). - PubMed
    1. ) Tsuruo , T. , Matsuzaki , T. , Matsushita , M. , Saito , H. and Yokokura , T.Antitumor effect of CPT‐11, a new derivative of camptothecin, against pleotropic drug‐resistant tumors in vitro and in vivo . Cancer Chem. Pharmacol. , 21 , 71 – 74 ( 1988. ). - PubMed
    1. ) Furuta , T. , Yokokura , T. and Mutai , M.Antitumor activity of CPT‐11 against rat Walker 256 carcinoma . Jpn. J. Cancer Chemother. , 15 , 2757 – 2760 ( 1988. ) ( in Japanese ). - PubMed
    1. ) Kawato , Y. , Yasuoka , M. and Matsumoto , K.The anti‐tumor effect and mechanism of action of CPT‐11, a camptothecin derivative . Proc. Jpn. Cancer Assoc., 46th Annu. Meet. , 408 ( 1987. ) ( in Japanese ).
    1. ) Andoh , T. , Ishü , K. and Suzuki , Y.Characterization of a mammalian mutant with a camptothecin‐resistant DNA topoisomerase I . Proc. Natl. Acad. Sci. USA , 84 , 5565 – 5569 ( 1987. ). - PMC - PubMed

Publication types

MeSH terms

LinkOut - more resources