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. 1994 Nov;138(3):963-71.
doi: 10.1093/genetics/138.3.963.

Empirical threshold values for quantitative trait mapping

G A Churchill  1 , R W Doerge
Affiliations

Empirical threshold values for quantitative trait mapping

G A Churchill et al. Genetics. 1994 Nov.

Abstract

The detection of genes that control quantitative characters is a problem of great interest to the genetic mapping community. Methods for locating these quantitative trait loci (QTL) relative to maps of genetic markers are now widely used. This paper addresses an issue common to all QTL mapping methods, that of determining an appropriate threshold value for declaring significant QTL effects. An empirical method is described, based on the concept of a permutation test, for estimating threshold values that are tailored to the experimental data at hand. The method is demonstrated using two real data sets derived from F(2) and recombinant inbred plant populations. An example using simulated data from a backcross design illustrates the effect of marker density on threshold values.

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References

    1. Proc Natl Acad Sci U S A. 1987 Apr;84(8):2363-7 - PubMed
    1. Biometrics. 1986 Sep;42(3):627-40 - PubMed
    1. Nature. 1988 Oct 20;335(6192):721-6 - PubMed
    1. Genetics. 1989 Jan;121(1):185-99 - PubMed
    1. Heredity (Edinb). 1992 Oct;69(4):315-24 - PubMed

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