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Noble Metal Complexes in Cancer Chemotherapy

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Inorganic and Nutritional Aspects of Cancer

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 91))

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  • 88 Citations

Abstract

Platinum coordination complexes form a new class of active anticancer agents in animals and man. Cis-dichlorodiammineplatinum(II), the most widely investigated drug, is now in experimental clinical use against a wide variety of cancers in man. The dose-limiting toxicity in man is renal tubular damage. Hydration of the patient and the use of osmotic diuretics have minimized this effect and allowed higher doses with largely improved responses. Combination chemotherapy with the drug has also produced significant response rates in a variety of cancers. The mode of action of the drug is not yet clear, but most likely involves a primary lesion on nuclear DNA and the stimulation of a host reaction to the cancer. So far, only square planar and octahedral complexes of platinum, with a variety of inorganic and organic ligands, have shown marked activity in animal studies.

This manuscript is, in large part, taken from a review paper that appeared in Die Naturwissenschaften 60, Pages 399-406, in 1973. New sections and some revisions have been made, updating the data.

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References

  1. Rosenberg, B., et al., Nature 222, Page 385, 1969.

    Article  PubMed  CAS  Google Scholar 

  2. Rosenberg, B., Platinum Metals Review 15, Page 3, 1971.

    Google Scholar 

  3. Gale, G. R., Handbuch der Experimentellen Pharmakologie, Springer Verlag, Berlin, Page 829, 1975.

    Google Scholar 

  4. Thomson, A. J., Williams, R. J. P., Reslova, S., Structure and Bonding 11, Page 1, 1972.

    Article  CAS  Google Scholar 

  5. Cleare, M. J., Hoeschele, J. D., Bioinorganic Chemistry 2, Page 187, 1973.

    Article  CAS  Google Scholar 

  6. Cleare, M. J., Hoeschele, J. D., Platinum Metals Review 17, Page 1, 1973.

    Google Scholar 

  7. Connors, T. A., et al., Chemico-Biol. Interactions 5, Page 415, 1972.

    Article  CAS  Google Scholar 

  8. Connors, T. A., Advances in Antimicrobial and Antineoplastic Chemotherapy 2, Page 237, University Park Press, Baltimore, 1972.

    Google Scholar 

  9. Conran, P. B., Rosenberg, B., ibid, Page 235.

    Google Scholar 

  10. Toth-Allen, J., Ph.D., Thesis, Michigan State University, 1970.

    Google Scholar 

  11. Hoeschele, J. D., VanCamp, L., Advances in Antimicrobial and Antineoplastic Chemotherapy 2 Page 241, University Park Press, Baltimore, 1972.

    Google Scholar 

  12. Ridgway, H. J., et al., Journal of Clinical Hematology and Oncology 7, No. 1, Page 220, 1977.

    CAS  Google Scholar 

  13. Lippert, B., et al., Journal of the American Chemical Society 99, Page 777, 1977.

    Article  Google Scholar 

  14. Lippert, B., et al., Journal of Inorganic Chemistry, in press, 1977.

    Google Scholar 

  15. Lippert, B., et al., ibid.

    Google Scholar 

  16. Howie, J. A., Gale, G. R., Biochem. Pharmacol. 19, 2757, 1970.

    Article  Google Scholar 

  17. Harder, H. C., Rosenberg, B., Int. J. Cancer 6, Page 207, 1970.

    Article  PubMed  CAS  Google Scholar 

  18. Hörer, O. L., Nicolau, C., F.E.B.S. Letters 14, Page 262, 1971.

    Article  Google Scholar 

  19. Stone, P. J., Sinex, F. M., Platinum Coordination Complexes in Cancer Chemotherapy (edited by T. A. Connors and J. J. Roberts) Page 68, Springer-Verlag, Berlin, 1974.

    Google Scholar 

  20. Van Den Berg, H. W., Fraval, H. N. A., and Roberts, J. J., Journal of Clinical Hematology and Oncology 7, No. 1, 349, 1977.

    Google Scholar 

  21. Roberts, J. J., Pascoe, J. M., Advances in Antimicrobial and Antineoplastic Chemotherapy 2, Page 249, University Park Press, Baltimore, 1972.

    Google Scholar 

  22. Mansy, S., Rosenberg, B., Thomson, A. J., Journal of the American Chemical Society 95, No. 5, 1973.

    Google Scholar 

  23. Thomson, A. J., Mansy, S., Advances in Antimicrobial and Antineoplastic Chemotherapy 2, Page 199, University Park Press, Baltimore, 1972.

    Google Scholar 

  24. Mansy, S., Rosenberg, B., unpublished results.

    Google Scholar 

  25. Theophanides, T., Macquet, J. P., Bioinorganic Chemistry 5, 1 Page 59, 1975.

    Article  PubMed  Google Scholar 

  26. Horacek, P., Drobnik, J., Biochim. Biophys. Acta. 254, 341, 1971.

    Article  PubMed  CAS  Google Scholar 

  27. Robins, A. B., Chem.-Biol. Interactions 6, Page 35, 1973.

    Article  CAS  Google Scholar 

  28. Robins, A. B., Chem.-Biol. Interactions 7, Page 11, 1973.

    Article  CAS  Google Scholar 

  29. Dixon, R. L. et al., Advances in Antimicrobial and Antineoplastic Chemocherapy 2, Page 243, University Park Press, Baltimore, 1972.

    Google Scholar 

  30. Kociba, R., Sleight, S. D., Cancer Chemother. Rep. 55, 1, 1971.

    PubMed  CAS  Google Scholar 

  31. Thompson, H. S., Gale, G. R., Toxicol. Appl. Pharmacol. 19, Page 602, 1971.

    Article  PubMed  CAS  Google Scholar 

  32. Zak, M., Drobnik, J., Rezny, Z., Cancer Research 32, 595, 1972.

    PubMed  CAS  Google Scholar 

  33. Rossof, A. H., Slayton, R. E., Perlia, C. P., Cancer 30, Page 1451, 1972.

    Article  PubMed  CAS  Google Scholar 

  34. Stadnicki, S. W., et al., F.A.S.E.B. Meeting Abstract, 1973.

    Google Scholar 

  35. Stadnicki, S. W., et al., Cancer Chemother. Rep., Part 1 59, No. 3, Page 467, 1975.

    PubMed  Google Scholar 

  36. Hayes, D., et al., Proceedings AACR 17, Page 169, 1976.

    Google Scholar 

  37. Woodman, R. J., et al., Proceedings American Association Cancer Research 12, Page 24, 1971.

    Google Scholar 

  38. Higby, D. J., et al., Cancer 33, Page 1219, 1974.

    Article  PubMed  CAS  Google Scholar 

  39. Wiltshaw, E., Kroner, T., Cancer Treatment Rep. 60, 55, 1976.

    CAS  Google Scholar 

  40. Wittes, R. E., et al., Journal of Clinical Hematology and Oncology 7, No. 2, April 1977.

    Google Scholar 

  41. Yagoda, A., et al., Cancer Treatment Reports 60, No. 7, Page 917, 1976.

    PubMed  CAS  Google Scholar 

  42. Bruckner, H. W., et al., Journal of Clinical Hematology and Oncology 7, No. 2, April 1977.

    Google Scholar 

  43. Einhorn, L. H., Furnas, B., Journal of Clinical Hematology and Oncology 7, No. 2, April 1977.

    Google Scholar 

  44. Merrin, C., AACR Abstracts, No. C-26, Page 243, May 1976.

    Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Biophysics, Michigan State University, East Lansing, Michigan, USA

    Barnett Rosenberg (Professor of Biophysics)

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  1. Barnett Rosenberg
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Editor information

Editors and Affiliations

  1. University of California at San Diego, La Jolla, California, USA

    G. N. Schrauzer

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© 1978 Plenum Press, New York

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Rosenberg, B. (1978). Noble Metal Complexes in Cancer Chemotherapy. In: Schrauzer, G.N. (eds) Inorganic and Nutritional Aspects of Cancer. Advances in Experimental Medicine and Biology, vol 91. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-0796-9_10

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  • DOI: https://doi.org/10.1007/978-1-4684-0796-9_10

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-0798-3

  • Online ISBN: 978-1-4684-0796-9

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