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Viral Vectors in Primate Research: Examples from Parkinson’s Disease Research

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Viral Vector Approaches in Neurobiology and Brain Diseases

Part of the book series: Neuromethods ((NM,volume 82))

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Abstract

Neurodegenerative diseases, such as Parkinson’s disease (PD), offer unique opportunities for the therapeutic application of viral vector gene transfer. In this chapter, we discuss the current state of viral vector preclinical development in nonhuman primate with special focus on vectors derived from adeno-associated virus (AAV) and lentivirus (LV), as they are the only ones that have reached clinical trials. We also outline desired features for improving the routes of delivery, tropism specificity, and other parameters that influence achievement of successful therapeutic goals.

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Abbreviations

6-OHDA:

6-Hydroxydopamine

AADC:

Aromatic l-amino acid decarboxylase

AAV:

Adeno-associated virus

CNS:

Central nervous system

D1:

Dopamine D1 receptors

D2:

Dopamine D2 receptors

GABA:

γ-Aminobutyric acid

GAD:

Glutamic acid decarboxylase

GCH:

Guanosine triphosphate cyclohydrolase I

GDNF:

Glial cell line-derived neurotrophic factor

GRKs:

G protein coupled receptor

GTPase:

Guanosine triphosphatase

l-DOPA:

l-3,4-Dihydroxyphenylalanine

LID:

l-DOPA-induced dyskinesia

LV:

Lentivirus

MPTP:

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine

MRI:

Magnetic resonance image

NPH:

Nonhuman primate

PD:

Parkinson’s disease

SN:

Substantia nigra

STN:

Subthalamic nucleus

TH:

Tyrosine hydroxylase

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Authors and Affiliations

  1. CNRS UMR 5293, Institut des Maladies Neurodégénératives, Université de Bordeaux, Bordeaux, France

    Grégory Porras & Benjamin Dehay

  2. CNRS, Institut des Maladies Neurodégénératives, Université de Bordeaux, Bordeaux, France

    Erwan Bezard

  3. Clinical Neurophysiology Department, Centre Hospitalier Universitaire, Hôpital Pellegrin, Bordeaux, France

    Erwan Bezard

Authors
  1. Grégory Porras
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  2. Benjamin Dehay
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  3. Erwan Bezard
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Editors and Affiliations

  1. Institute of Experimental Neurology, San Raffaele Scientific Institute Division of Neuroscience, Milan, Italy

    Riccardo Brambilla

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Porras, G., Dehay, B., Bezard, E. (2014). Viral Vectors in Primate Research: Examples from Parkinson’s Disease Research. In: Brambilla, R. (eds) Viral Vector Approaches in Neurobiology and Brain Diseases. Neuromethods, vol 82. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-610-8_17

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