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Fatigue in women treated with bone marrow transplantation for breast cancer: A comparison with women with no history of cancer

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Abstract

As more individuals undergo autologous bone marrow transplantation (BMT), there is growing interest in the impact of treatment side effects on quality of life. Fatigue is a potentially disruptive treatment side effect that has not been systematically assessed following BMT. The primary aim of this study was to determine whether the severity of fatigue and its impact on quality of life is significantly greater in women who had undergone BMT for breast cancer than in women of similar age with no history of cancer. Another aim was to identify the medical and psychosocial correlates of fatigue in women who had completed BMT. A group of women treated with autologous BMT for breast cancer (n = 43; mean age = 44; mean time since BMT = 20 months) and a group of women of similar age with no history of cancer (n = 43; mean age = 46) participated in this study. Subjects completed measures of fatigue, anxiety, depression, and sleep habits. Medical data were obtained from computerized patient records. Women who had completed BMT for breast cancer reported significantly more frequent and severe fatigue than women with no cancer history. In addition, fatigue had a significantly greater impact on daily functioning and quality of life in BMT recipients than in women with no cancer history. Fatigue following BMT for breast cancer was related to both medical factors (i.e., time since BMT) and psychosocial factors (i.e., anxiety, depressive symptoms and sleep difficulties). Following BMT for breast cancer, women may experience fatigue that is worse than might “normally” be expected and can interfere with daily functioning and quality of life. Future research should focus on identifying the biological correlates of fatigue, psychological and physiological mechanisms by which fatigue is produced, and interventions to alleviate fatigue.

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References

  1. Ahles TA, Martin JB (1992) Cancer pain: a multidimensional perspectiv. Noninvasive approaches to pain management in the terminally ill. Hospice J 8:25–48

    Google Scholar 

  2. Ahles TA, Tope DM, Furstenberg C, et al (1996) Psychological and neuropsychological impact of autologous bone marrow transplantation. J Clin Oncol (in press)

  3. Aistairs J (1987) Fatigue in the cancer patient: a conceptual approach to a clinical problem. Oncol Nurs Forum 14:25–30

    Google Scholar 

  4. Andrykowski MA, Henslee PJ, Farrall MG (1989) Physical and psychosocial functioning of adult survivors of allogeneic bone marrow transplantation. Bone Marrow Transplant 4:75–81

    PubMed  Google Scholar 

  5. Baker F, Wingard JR, Cubrow B, et al (1994) Quality of life of bone marrow transplant long-term survivors. Bone Marrow Transplant 13:589–596

    PubMed  Google Scholar 

  6. Berkman CF, Berkman CS, Kasl S, et al (1986) Depressive symptoms in relation to physical health and functioning in the elderly. Am J Epidemiol 124:372–388

    PubMed  Google Scholar 

  7. Bruera E, MacDonald RN (1988) Asthenia in patients with advanced cancer. J Pain Symptom Manage 3:9–14

    PubMed  Google Scholar 

  8. Bush NE, Haberman M, Donaldson G, et al (1995) Quality of life of 125 adults surviving 6–18 years after bone marrow transplantation. Soc Sci Med 40:479–490

    PubMed  Google Scholar 

  9. Buysse DJ, Reynolds CF, Monk TH, et al (1989) The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research. J Psychiatr Res 28:193–213

    Google Scholar 

  10. Cella DF, Tross S, Orav EJ, et al (1989) Mood states of patients after the diagnosis of cancer. J Psychosoc Oncol 7:45–54

    Google Scholar 

  11. Fields KK, Elfenbein GJ, Perkins JB, et al (1993) Two novel high dose treatment regimens for metastatic breast cancer: ifosfamide, carboplatin, plus etoposide (ICE) and mitoxantrone plus thiotepa (MITT): outcomes and toxicities. Semin Oncol 20[Suppl 6]:59–66

    PubMed  Google Scholar 

  12. Fields KK, Elfenbein GJ, Perkins JB, et al (1994) High dose versus standard dose chemotherapy for the treatment of breast cancer: a review of current concepts. In: Sackstein R, Janssen W, Elfenbein G (eds) Bone marrow transplantation: foundations for the 21st century. The New York Academy of Sciences, New York, pp 288–304

    Google Scholar 

  13. Fields KK, Elfenbein GJ, Lazarus HM, et al (1995) Maximum tolerated doses of ifosfamide, carboplatin, and etoposide given over six days followed by autologous stem cell rescue: toxicity profile. J Clin Oncol 13:323–332

    PubMed  Google Scholar 

  14. Fields K, Perkins J, Elfenbein G, et al (1995) A phase I dose escalation trial of high dose TAXOL, NOVAN-TRONE, and thioTEPA (TNT) followed by autologous stem cell rescue (ASCR): toxicity. Proc ASCO 14:322

    Google Scholar 

  15. Haberman M, Bush N, Young K, et al (1993) Quality of life of adult longterm survivors of bone marrow transplantation: a qualitative analysis of narrative data. Oncol Nurs Forum 20:1545–1553

    PubMed  Google Scholar 

  16. Hadjistavropoulos HD, Craig KD (1994) Acute and chronic low back pain: cognitive, affective, and behavioral dimensions. J Consult Clin Psychol 62:341–349

    PubMed  Google Scholar 

  17. Magni G, Caldieron C, Rigatti-Luchini S, et al (1990) Chronic musculoskeletal pain and depressive symptoms in the general population: an analysis of the 1st National Health and Nutrition Examination Survey data. Pain 43:299–307

    PubMed  Google Scholar 

  18. McKenzie R, Straus SE (1995) Chronic fatigue syndrome. Adv Intern Med 40:119–153

    PubMed  Google Scholar 

  19. McNair DM, Lorr M, Droppleman LF (1981) The manual for the profile of mood states. Educational and Industrial Testing Service, San Diego

    Google Scholar 

  20. Nail LM, Winningham ML (1993) Fatigue. In: Groenwald S, Goodman M, Frogge MH, Yarbo CH (eds) Cancer nursing: principles and practice, 3rd edn. Jones and Bartlett, Boston, pp 608–619

    Google Scholar 

  21. Radloff LS (1977) The CES-D Scale: a self-report depression scale for research in the general population. Appl Psychol Meas 1:385–401

    Google Scholar 

  22. Spielberger CD, Gorsuch RL, Lushene RD (1970) STAI: Manual for the State-Trait Anxiety Inventory. Consulting Psychologists Press, Palo Alto

    Google Scholar 

  23. Stommel M, Given BA, Given CW, et al (1993) Gender bias in the measurement properties of the Center for Epidemiologic Studies Depression Scale (CES-D). Psychiatry Res 49:239–250

    PubMed  Google Scholar 

  24. Sullivan KM, Mori M, Sanders J, et al (1992) Late complications of allogeneic and autologous marrow transplantation. Bone Marrow Transplant 10 [Suppl 1]:127–134

    PubMed  Google Scholar 

  25. Winningham ML, Nail LM, Burke MB, et al (1994) Fatigue and the cancer experience: the state of the knowledge. Oncol Nurs Forum 21:23–36

    PubMed  Google Scholar 

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Author notes

  1. Danette M. Hann

    Present address: Behavioral Research Center, American Cancer Society, 1599 Clifton Road, N.E., 30329-4251, Atlanta, GA, USA

Authors and Affiliations

  1. Psychosocial Oncology Program, H. Lee Moffitt Cancer Center and Research Institute, University of South Florida, 12902 Magnolia Drive, 33612, Tampa, FL, USA

    Danette M. Hann, Paul B. Jacobsen, Staci C. Martin & Lora M. Azzarello

  2. Bone Marrow Transplantation Program, H. Lee Moffitt Cancer Center and Research Institute, University of South Florida, 12902 Magnolia Drive, 33612, Tampa, FL, USA

    Lori E. Kronish & Karen K. Fields

Authors
  1. Danette M. Hann
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  2. Paul B. Jacobsen
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  3. Staci C. Martin
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  4. Lori E. Kronish
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  5. Lora M. Azzarello
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  6. Karen K. Fields
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Hann, D.M., Jacobsen, P.B., Martin, S.C. et al. Fatigue in women treated with bone marrow transplantation for breast cancer: A comparison with women with no history of cancer. Support Care Cancer 5, 44–52 (1997). https://doi.org/10.1007/BF01681961

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