Skip to main content

Advertisement

Springer Nature Link
Log in

Genetic variability of interleukin-1 beta as prospective factor from developing post-traumatic stress disorder

  • Short Communication
  • Published:
Immunogenetics Aims and scope Submit manuscript

Abstract

Individual susceptibility to post-traumatic stress disorder (PTSD) is conditioned by genetic factors, and association between this disorder and polymorphisms of several genes have been shown. The aim of this study was to explore a potential association between single nucleotide polymorphisms (SNP) of the IL-1β gene (IL1B) and PTSD. In genomic DNA samples of PTSD-affected and healthy subjects, the rs16944, rs1143634, rs2853550, rs1143643, and rs1143633 SNPs of IL1B gene have been genotyped. The results obtained demonstrated that IL1B rs1143633*C and rs16944*A minor allele frequency were significantly lower in patients than in controls. Our results confirm that IL1B rs1143633 and rs16944 SNPs are negatively associated with PTSD which allows us to consider them as protective variants for PTSD. IL1B rs1143633*C and rs16944*A minor allele frequencies and carriage rates are significantly lower in the PTSD patients as compared to the controls. These results may provide a base to conclude that above-mentioned alleles can be protective against PTSD, and IL1B gene can be involved in the pathogenesis of this disorder.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Subscribe and save

Springer+ Basic
€34.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or eBook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price includes VAT (Germany)

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

Explore related subjects

Discover the latest articles and news from researchers in related subjects, suggested using machine learning.

References

  • Apte, Voronov (2002) Interleukin-1—a major pleiotropic cytokine in tumor-host interactions. Semin Cancer Biol 12(4):277–290

    Article  CAS  PubMed  Google Scholar 

  • Arman A, Soylu O, Yildirim A, Furman A, Ercelen N, Aydogan H, Coker A, Tezel T (2008) Interleukin-1 receptor antagonist gene VNTR polymorphism is associated with coronary artery disease. Arq Bras Cardiol 91(5):293–298

    Article  CAS  PubMed  Google Scholar 

  • Azarian A, Skriptchenko-Gregorian V (1998) Children in natural disasters: an experience of the 1988 earthquake in Armenia. American Academy of Experts in Traumatic Stress, US www.aaets.org/article38.htm

    Google Scholar 

  • Bakunts AG (1994) Mental disorders among Armenian volunteers fighting in Karabakh. Bekhterev rev. Psychiatr Med Psychology 2:7–79

    Google Scholar 

  • Baune BT, Dannlowski U, Domschke K, Janssen DG, Jordan MA et al (2010) The interleukin 1 beta (IL1B) gene is associated with failure to achieve remission and impaired emotion processing in major depression. Biol Psychiatry 15;67(6):543–549

    Article  Google Scholar 

  • Blake DD, Weathers FW, Nagy LM, Kaloupek DG, Gusman FD, Charney DS, Keane TM (1995) The development of a clinician administered PTSD scale. J Trauma Stress 8(1):75–90

    Article  CAS  PubMed  Google Scholar 

  • Brandes D, Ben-Schachar G, Gilboa A, Bonne O, Freedman S, Shalev AY (2002) PTSD symptoms and cognitive performance in recent trauma survivors. Psychiatry Res 31; 110(3):231–238

    Article  Google Scholar 

  • Brydon L, Edwards S, Jia H, Mohamed-Ali V, Zachary I, Martin JF, Steptoe A (2005) Psychological stress activates interleukin-1beta gene expression in human mononuclear cells. Brain Behav Immun 19(6):540–546

    Article  CAS  PubMed  Google Scholar 

  • Bunce M, O’Neil CM, Barnado MC, Krausa P, Browning MJ, Morris PJ (1995) Phototyping: comprehensive DNA typing for HLA-A, B, C, DRB3, DRB4, DRB5 & DQB1 by PCR with 144 primer mixes utilizing sequence-specific primers (PCRSSP). Tissue Antigens 46:355–367

    Article  CAS  PubMed  Google Scholar 

  • Dantzer R (2009) Cytokine, sickness behavior, and depression. Immunol Allergy Clin N Am 29(2):247–264

    Article  Google Scholar 

  • Di Bona D, Plaia A, Vasto S, Cavallone L, Lescai F, Franceschi C, Licastro F, Colonna-Romano G, Lio D, Candore G, Caruso C (2008) Association between the interleukin-1beta polymorphisms and Alzheimer's disease: a systematic review and meta-analysis. Brain Res Rev 59(1):155–163

    Article  PubMed  Google Scholar 

  • DSM-IV-TR (2000) Diagnostic and statistical manual of mental disorders by the American Psychiatric Association, edition: 4, text revised. The American Psychiatric Association, Virginia

    Google Scholar 

  • DSM-V (2000) Diagnostic and statistical manual of mental disorders by the American Psychiatric Association, edition: 5, text revised. The American Psychiatric Association

  • Fatjó-Vilas M, Pomarol-Clotet E, Salvador R, Monté GC, Gomar JJ, Sarró S, Ortiz-Gil J, Aguirre C, Landín-Romero R, Guerrero-Pedraza A, Papiol S, Blanch J, McKenna PJ, Fañanás L (2012) Effect of the interleukin-1β gene on dorsolateral prefrontal cortex function in schizophrenia: a genetic neuroimaging study. Biol Psychiatry 72(9):758–765

    Article  PubMed  Google Scholar 

  • First MB, Spitzer RL, Gibbon M, Williams JB (1997) Structured clinical interview for the DSM-IV® axis I disorders (SCID-I), clinician version, user's guide. Am Psych Press Inc, USA

    Google Scholar 

  • Geismar K, Enevold C, Sørensen LK, Gyntelberg F, Bendtzen K, Sigurd B, Holmstrup P (2008) Involvement of interleukin-1 genotypes in the association of coronary heart disease with periodontitis. J Periodontol 79(12):2322–2330

    Article  CAS  PubMed  Google Scholar 

  • Gill JM, Saligan L, Woods S, Page G (2009) PTSD is associated with an excess of inflammatory immune activities. Perspect Psychiatr Care 45(4):262–277

    Article  PubMed  Google Scholar 

  • Goenjian A (1993) A mental health relief programme in Armenia after the 1988 earthquake. Implementation and clinical observations. Br J Psychiatry 63:230–239

    Article  Google Scholar 

  • Goenjian AK, Najarian LM, Pynoos RS, Steinberg AM, Manoukian G, Tavosian A, Fairbanks LA (1994) Posttraumatic stress disorder in elderly and younger adults after the 1988 earthquake in Armenia. Am J Psychiatry 151(6):895–901

    Article  CAS  PubMed  Google Scholar 

  • Goenjian AK, Pynoos RS, Steinberg AM, Endres D, Abraham K, Geffner ME, Fairbanks LA (2003) Hypothalamic-pituitary-adrenal activity among Armenian adolescents with PTSD symptoms. J Traumatic Stress 16(4):319–323

    Article  Google Scholar 

  • Hong H, Kim BS, Im HI (2016) Pathophysiological role of neuroinflammation in neurodegenerative diseases and psychiatric disorders. Int Neurourol 20(1):S2–S7

    Article  Google Scholar 

  • Hovhannisyan LP, Mkrtchyan GM, Boyajyan AS, Sukiasian SH (2008) Immune complexes and complement classical cascade in posttraumatic stress disorder. Russ Biomed J 9(2):269–274

    Google Scholar 

  • Hovhannisyan LP, Mkrtchyan GM, Sukiasian SH, Boyajyan AS (2010) Alterations in the complement cascade in post-traumatic stress disorder. Allergy Asthma Clin Immunol 21; 6(1):3. doi:10.1186/1710-1492-6-3

    Article  Google Scholar 

  • Hovhannisyan LP, Mkrtchyan GM, Boyajyan AS, Avetyan DG, Tadevosyan МY, Sukiasyan SH (2012) Inflammatory markers in post-traumatic stress disorder. Cytokines and Inflammation 11(1):42–45

    Google Scholar 

  • ICD-10 (1992) The international statistical classification of diseases and related health problems, Edition: 10 edn. World Health Organization, Geneva

    Google Scholar 

  • Karenian H, Livaditis M, Karenian S, Zafiriadis K, Bochtsou V, Xenitidis K (2011) Collective trauma transmission and traumatic reactions among descendants of Armenian refugees. Int J Soc Psychiatry 57(4):327–337

    Article  PubMed  Google Scholar 

  • Kilaru V, Iyer SV, Almli LM, Stevens JS, Lori A, Jovanovic T, Ely TD, Bradley B, Binder EB, Koen N, Stein DJ, Conneely KN, Wingo AP, Smith AK, Ressler KJ (2016) Genome-wide gene-based analysis suggests an association between Neuroligin 1 (NLGN1) and post-traumatic stress disorder. Transl Psychiatry 24(6):e820

    Article  Google Scholar 

  • Koo JW, Duman RS (2008) IL-1beta is an essential mediator of the antineurogenic and anhedonic effects of stress. Proc Natl Acad Sci U S A 15; 105(2):751–756

    Article  Google Scholar 

  • Lalouel JM, Rohrwasser A (2002) Power and replication in case-control studies. Am J Hypertens 15(2–1):201–205

    Article  PubMed  Google Scholar 

  • Mastrolonardo M, Alicino D, Zefferino R, Pasquini P, Picardi A (2007) Effect of psychological stress on salivary interleukin-1beta in psoriasis. Arch Med Res 38(2):206–211

    Article  CAS  PubMed  Google Scholar 

  • Miklowitz DJ, Portnoff LC, Armstrong CC, Keenan-Miller D, Breen EC, Muscatell KA, Eisenberger NI, Irwin MR (2016) Inflammatory cytokines and nuclear factor-kappa B activation in adolescents with bipolar and major depressive disorders. Psychiatry Res 30(241):315–322

    Article  Google Scholar 

  • Miller SA, Dykes DD, Polesky HF (1988) A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res 16(3):1215

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Montoya-Ruiz C, Jaimes FA, Rugeles MT, López JÁ, Bedoya G, Velilla PA (2016) Variants in LTA, TNF, IL1B and IL10 genes associated with the clinical course of sepsis. Immunol Res 64(5–6):1168–1178

    Article  CAS  PubMed  Google Scholar 

  • Pervanidou P (2008) Biology of post-traumatic stress disorder in childhood and adolescence. J Neuroendocrinol 20(5):632–638

    Article  CAS  PubMed  Google Scholar 

  • Sánchez E, Sabio JM, Callejas JL, de Ramón E, Garcia-Portales R, García-Hernández FJ, Jiménez-Alonso J, González-Escribano MF, Martín J, Koeleman BP (2006) Association study of genetic variants of pro-inflammatory chemokine and cytokine genes in systemic lupus erythematosus. BMC Med Genet 23(7):48

    Article  Google Scholar 

  • Sasayama D, Hori H, Teraishi T, Hattori K, Ota M, Matsuo J, Kawamoto Y, Kinoshita Y, Higuchi T, Amano N, Kunugi H (2011) Association of interleukin-1β genetic polymorphisms with cognitive performance in elderly females without dementia. J Hum Genet 56(8):613–616

    Article  CAS  PubMed  Google Scholar 

  • Spangelo BL, Judd AM, Call GB, Zumwalt J, Gorospe WC (1995) Role of the cytokines in the hypothalamic-pituitary-adrenal and gonadal axes. Neuroimmunomodulation 2:299–312

    Article  CAS  PubMed  Google Scholar 

  • Steptoe A, Tsuda A, Tanaka Y, Wardle J (2007) Depressive symptoms, socio-economic background, sense of control, and cultural factors in university students from 23 countries. Int J Behav Med 14(2):97–107

    Article  PubMed  Google Scholar 

  • Sukiasyan SH, Tadevosyan MJ (2010) Posttraumatic stress disorder: medical and social—psychological problem in Armenia. Russ J Psychiatry 5:59–69

    Google Scholar 

  • Tadić A, Rujescu D, Müller MJ, Kohnen R, Stassen HH, Szegedi A, Dahmen N (2008) Association analysis between variants of the interleukin-1beta and the interleukin-1 receptor antagonist gene and antidepressant treatment response in major depression. Neuropsychiatr Dis Treat 4(1):269–276

    PubMed  PubMed Central  Google Scholar 

  • Von Känel R, Hepp U, Kraemer B, Traber R, Keel M, Mica L, Schnyder U (2007) Evidence for low-grade systemic proinflammatory activity in patients with posttraumatic stress disorder. J Psychiatr Res 41(9):744–752

    Article  Google Scholar 

  • Wang Z, Mandel H, Levingston CA, Young MR (2016) An exploratory approach demonstrating immune skewing and a loss of coordination among cytokines in plasma and saliva of veterans with combat-related PTSD. Hum Immunol 77(8):652–627

    Article  CAS  PubMed  Google Scholar 

  • Wessa M, Rohleder N (2007) Endocrine and inflammatory alterations in post-traumatic stress disorder. Expert Rev Endocrinol Metab 2(1):91–122

    Article  CAS  Google Scholar 

  • Wong CM (2002) Post-traumatic stress disorder: advances in psychoneuroimmunology. Psychiatr Clin North Am 25(2):369–383 vii

    Article  PubMed  Google Scholar 

  • Yamakawa K, Matsunaga M, Isowa T, Kimura K, Kasugai K, Yoneda M, Kaneko H, Ohira H (2009) Transient responses of inflammatory cytokines in acute stress. Biol Psychol 82(1):25–32

    Article  PubMed  Google Scholar 

  • Yoshida M, Shiroiwa K, Mouri K, Ishiguro H, Supriyanto I, Ratta-Apha W et al (2012) Haplotypes in the expression quantitative trait locus of interleukin-1β gene are associated with schizophrenia. Schizophr Res 140:185–191

    Article  PubMed  Google Scholar 

  • Yu YW, Chen TJ, Hong CJ, Chen HM, Tsai SJ (2003) Association study of the interleukin-1 beta (C-511T) genetic polymorphism with major depressive disorder, associated symptomatology, and antidepressant response. Neuropsychopharmacology 28(6):1182–1185

    CAS  PubMed  Google Scholar 

Download references

Acknowledgements

The authors express their gratitude to the administration and medical staff of the Stress Center (Ministry of Labor and Social Affairs of the Republic of Armenia) and Stepanakert Rehabilitation Center (Ministry of Health of Nagorno Karabakh Republic) for selection of PTSD patients for this study. The study was supported by the grant of the Armenian National Science and Education Fund (# NS-molbio-3805).

Author information

Authors and Affiliations

  1. Institute of Molecular Biology, Armenian National Academy of Sciences, Hasratyan 7 street, 0014, Yerevan, Armenia

    Lilit Hovhannisyan, Ani Stepanyan & Arsen Arakelyan

Authors
  1. Lilit Hovhannisyan
    View author publications

    Search author on:PubMed Google Scholar

  2. Ani Stepanyan
    View author publications

    Search author on:PubMed Google Scholar

  3. Arsen Arakelyan
    View author publications

    Search author on:PubMed Google Scholar

Corresponding author

Correspondence to Lilit Hovhannisyan.

Electronic supplementary material

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Hovhannisyan, L., Stepanyan, A. & Arakelyan, A. Genetic variability of interleukin-1 beta as prospective factor from developing post-traumatic stress disorder. Immunogenetics 69, 703–708 (2017). https://doi.org/10.1007/s00251-017-1016-4

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00251-017-1016-4

Keywords

Profiles

  1. Ani Stepanyan View author profile