The p62 protein recognizes toxic cellular waste, which is then scavenged by a sequestration process known as self-eating or autophagy. Lack of autophagy leads to accumulation of p62, which is not good for liver cells, as it induces a cellular stress response that leads to disease.
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Rusten, T., Stenmark, H. p62, an autophagy hero or culprit?. Nat Cell Biol 12, 207–209 (2010). https://doi.org/10.1038/ncb0310-207
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DOI: https://doi.org/10.1038/ncb0310-207
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