Vol 21, No 5 (2014)Effect of carvedilol on silent anthracycline-induced cardiotoxicity assessed by strain imaging: A prospective randomized controlled study with six-month follow-up
Effect of carvedilol on silent anthracycline-induced cardiotoxicity assessed by strain imaging: A prospective randomized controlled study with six-month follow-up
Ali Elitok, Fahrettin Oz, Ahmet Y. Cizgici, Leyla Kilic, Rumeysa Ciftci, Fatma Sen, Zehra Bugra, Fehmi Mercanoglu, Aytac Oncul, Huseyin Oflaz
');
var $authorName = $('').appendTo($authorBox);
$authorName.html($span.find(".author-name").html());
if ($span.find(".orcid-link").length) {
var $orcid = $span.find(".orcid-link");
$orcid.clone().appendTo($authorBox).append($('' + $orcid.attr("data-orcid-id") + ''));
}
$span.find("sup").each(function() {
var $affiliation = $(this);
$('
Background: The use of antracycline (ANT) in breast cancer has been associated with adverse cardiac events. Two-dimensional (2D) strain imaging (SI) can provide a more sensitive measure of altered left ventricular (LV) systolic function. We aimed to evaluate the preventive effect of carvedilol administration assessed by SI in a patient with breast cancer treated with ANT.
Methods: Patients receiving ANT were randomly assigned to the carvedilol- or placebo-receiving group. Each received an echocardiographic examination with conventional 2D echocardiography, pulsed tissue Doppler, and 2D SI prior to and 6 months post ANT treatment.
Results: During the 6-month follow-up period there were no patient deaths or interrupted chemotherapy treatments due to doxorubicin-induced cardiotoxicity. Both left ventricular ejection fraction (LVEF) and fractional shortening (FS) were within normal limits for all patients before and after ANT therapy. EF, FS and LV dimensions were measured using M-mode echocardiography and found to be similar in both groups before and after ANT therapy. The mean EF, FS, and LV echocardiograph baseline and control dimensions were similar in both groups after 6 months. Though baseline SI parameters were similar between the groups, there was a significant decrease in LV basal septal and basal lateral peak systolic strain in the control group compared to the carvedilol group.
Conclusions: These results indicate that carvedilol has a protective effect against the cardiotoxicity induced by ANT.
We use cookies on our website. We use them to ensure the proper functioning of the site and, if you give us your consent, for purposes we set, such as analytics or marketing. We would like to ask your permission to store them on your device. We will not run optional cookies until you have enabled them yourself. If you would like to learn more about how cookies work and how we process personal data related to them, please visit our Privacy Policy page
About cookies
Necessary cookies
Allways active
These cookies are necessary for the proper display and operation of the website. Blocking them may cause the website to malfunction.
Analytical cookies
As part of our website, we use analytical tools, such as Google Analytics, that allow us to verify website traffic. These tools may require the use of cookies.
Community cookies
These are cookies associated with the social networks we use. Accepting them will allow us to associate your visit to the site with our social media profiles.
Marketing cookies
These are cookies responsible for carrying out advertising and marketing activities - consenting to their use will allow us to target you with advertisements based on your previous activities within our website.
