Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1982;24(2):67-73.
doi: 10.1159/000137578.

Differential induction of sister chromatid exchange by chemical carcinogens in lymphocytes cultured from patients with solid tumors

J K Wiencke, J Vosika, P Johnson, N Wang, V F Garry

Differential induction of sister chromatid exchange by chemical carcinogens in lymphocytes cultured from patients with solid tumors

J K Wiencke et al. Pharmacology. 1982.

Abstract

Three carcinogens with different requirements for activation were used to generate sister chromatid exchange (SCE) in cultured lymphocytes from 22 untreated patients with solid tumors. These data were compared to SCEs produced by incubating lymphocytes, from 44 normal persons, with the same carcinogens. In vitro treatments with butadiene epoxide (0.125 micrograms/ml) show no significant differences in the SCEs generated. However, in vitro treatment with mitomycin-C (0.04 micrograms/ml) did induce significant differences (p less than 0.05) in the distribution of the SCE scores. Treatment of the cultured cells with benzo(a)pyrene (10 micrograms/ml), a carcinogen requiring extensive metabolic activation, significantly (p less than 0.001) altered the distribution of the SCEs generated in vitro. The SCE data suggest that metabolic activities play an important role in the processing of carcinogens in solid tumor patients.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

LinkOut - more resources