Network Pharmacology in Research of Chinese Medicine Formula: Methodology, Application and Prospective

doi:10.1007/s11655-019-3064-0

Review

. 2020 Jan;26(1):72-80.

doi: 10.1007/s11655-019-3064-0. Epub 2019 Apr 2.

Network Pharmacology in Research of Chinese Medicine Formula: Methodology, Application and Prospective

Ting-Ting Luo^{1

2}, Yuan Lu^{1

2}, Shi-Kai Yan³, Xue Xiao^{1

2}, Xiang-Lu Rong^{1

2}, Jiao Guo^{4

5}

Affiliations

¹ Institute of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou, 510006, China.
² Guangdong Metabolic Diseases Research Center of Integrated Chinese and Western Medicine, Guangzhou, 510006, China.
³ School of Pharmacy, Shanghai Jiao Tong University, Shanghai, 200240, China.
⁴ Institute of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou, 510006, China. [email protected].
⁵ Guangdong Metabolic Diseases Research Center of Integrated Chinese and Western Medicine, Guangzhou, 510006, China. [email protected].

PMID: 30941682
DOI: 10.1007/s11655-019-3064-0

Review

Network Pharmacology in Research of Chinese Medicine Formula: Methodology, Application and Prospective

Ting-Ting Luo et al. Chin J Integr Med. 2020 Jan.

. 2020 Jan;26(1):72-80.

doi: 10.1007/s11655-019-3064-0. Epub 2019 Apr 2.

Authors

Ting-Ting Luo^{1

2}, Yuan Lu^{1

2}, Shi-Kai Yan³, Xue Xiao^{1

2}, Xiang-Lu Rong^{1

2}, Jiao Guo^{4

5}

Affiliations

¹ Institute of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou, 510006, China.
² Guangdong Metabolic Diseases Research Center of Integrated Chinese and Western Medicine, Guangzhou, 510006, China.
³ School of Pharmacy, Shanghai Jiao Tong University, Shanghai, 200240, China.
⁴ Institute of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou, 510006, China. [email protected].
⁵ Guangdong Metabolic Diseases Research Center of Integrated Chinese and Western Medicine, Guangzhou, 510006, China. [email protected].

PMID: 30941682
DOI: 10.1007/s11655-019-3064-0

Abstract

Chinese medicine (CM) is usually prescribed as CM formula to treat disease. The lack of effective research approach makes it difficult to elucidate the molecular mechanisms of CM formula owing to its complicated chemical compounds. Network pharmacology is increasingly applied in CM formula research in recent years, which is identified suitable for the study of CM formula. In this review, we summarized the methodology of network pharmacology, including network construction, network analysis and network verification. The aim of constructing a network is to achieve the interaction between the bioactive compounds and targets and the interaction between various targets, and then find out and validate the key nodes via network analysis and network verification. Besides, we reviewed the application in CM formula research, mainly including targets discovery, bioactive compounds screening, toxicity evaluation, mechanism research and quality control research. Finally, we proposed prospective in the future and limitations of network pharmacology, expecting to provide new strategy and thinking on study for CM formula.

Keywords: Chinese medicine formula; mechanism research; network pharmacology; quality control research; targets discovery.

PubMed Disclaimer

Cited by

Integrating Network Pharmacology and Experimental Validation to Decipher the Mechanism of Action of Huanglian Jiedu Decoction in Treating Atherosclerosis.
Liang J, Huang Y, Mai Z, Zhan Q, Lin H, Xie Y, Wang H, Liu Y, Luo C. Liang J, et al. Drug Des Devel Ther. 2021 Apr 30;15:1779-1795. doi: 10.2147/DDDT.S304911. eCollection 2021. Drug Des Devel Ther. 2021. PMID: 33958856 Free PMC article.
Network pharmacology and molecular docking-based prediction of active compounds and mechanisms of action of Cnidii Fructus in treating atopic dermatitis.
Khan SA, Wu Y, Li AS, Fu XQ, Yu ZL. Khan SA, et al. BMC Complement Med Ther. 2022 Oct 19;22(1):275. doi: 10.1186/s12906-022-03734-7. BMC Complement Med Ther. 2022. PMID: 36261841 Free PMC article.
Acteoside and ursolic acid synergistically protects H₂O₂-induced neurotrosis by regulation of AKT/mTOR signalling: from network pharmacology to experimental validation.
Qu YJ, Ding MR, Gu C, Zhang LM, Zhen RR, Chen JF, Hu B, An HM. Qu YJ, et al. Pharm Biol. 2022 Dec;60(1):1751-1761. doi: 10.1080/13880209.2022.2098344. Pharm Biol. 2022. PMID: 36102631 Free PMC article.
Network pharmacology-based investigation and experimental validation of the mechanism of scutellarin in the treatment of acute myeloid leukemia.
Huang Z, Yang Y, Fan X, Ma W. Huang Z, et al. Front Pharmacol. 2022 Sep 7;13:952677. doi: 10.3389/fphar.2022.952677. eCollection 2022. Front Pharmacol. 2022. PMID: 36160389 Free PMC article.
QiDiTangShen granules alleviates diabetic nephropathy podocyte injury: A network pharmacology study and experimental validation in vivo and vitro.
Gao F, Zhou Y, Yu B, Xie H, Shi Y, Zhang X, Liu H. Gao F, et al. Heliyon. 2023 Dec 10;10(1):e23535. doi: 10.1016/j.heliyon.2023.e23535. eCollection 2024 Jan 15. Heliyon. 2023. PMID: 38223704 Free PMC article.

See all "Cited by" articles

References

1. PLoS One. 2014 Mar 05;9(3):e89123 - PubMed
1. Nat Chem Biol. 2008 Nov;4(11):682-90 - PubMed
1. Chin J Integr Med. 2016 Dec;22(12):883-888 - PubMed
1. Yao Xue Xue Bao. 2011 Aug;46(8):877-82 - PubMed
1. J Ethnopharmacol. 2013 Nov 25;150(2):619-38 - PubMed

Publication types

Actions

MeSH terms

Actions
Actions
Actions
Actions

Substances

Actions

LinkOut - more resources

Full Text Sources
- Springer

[1] PLoS One. 2014 Mar 05;9(3):e89123 - PubMed

[2] PLoS One. 2014 Mar 05;9(3):e89123 - PubMed

[3] Nat Chem Biol. 2008 Nov;4(11):682-90 - PubMed

[4] Nat Chem Biol. 2008 Nov;4(11):682-90 - PubMed

[5] Chin J Integr Med. 2016 Dec;22(12):883-888 - PubMed

[6] Chin J Integr Med. 2016 Dec;22(12):883-888 - PubMed

[7] Yao Xue Xue Bao. 2011 Aug;46(8):877-82 - PubMed

[8] Yao Xue Xue Bao. 2011 Aug;46(8):877-82 - PubMed

[9] J Ethnopharmacol. 2013 Nov 25;150(2):619-38 - PubMed

[10] J Ethnopharmacol. 2013 Nov 25;150(2):619-38 - PubMed

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Network Pharmacology in Research of Chinese Medicine Formula: Methodology, Application and Prospective

Affiliations

Network Pharmacology in Research of Chinese Medicine Formula: Methodology, Application and Prospective

Authors

Affiliations

Abstract

Similar articles

Cited by

References

Publication types

MeSH terms

Substances

LinkOut - more resources

Full Text Sources