doi: 10.1074/jbc.272.34.20975.
Molecular cloning of a non-inactivating proton-gated Na+ channel specific for sensory neurons
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- PMID: 9261094
- DOI: 10.1074/jbc.272.34.20975
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Molecular cloning of a non-inactivating proton-gated Na+ channel specific for sensory neurons
J Biol Chem.
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Free article
Abstract
We have cloned and expressed a novel proton-gated Na+ channel subunit that is specific for sensory neurons. In COS cells, it forms a Na+ channel that responds to a drop of the extracellular pH with both a rapidly inactivating and a sustained Na+ current. This biphasic kinetic closely resembles that of the H+-gated current described in sensory neurons of dorsal root ganglia (1). Both the abundance of this novel H+-gated Na+ channel subunit in sensory neurons and the kinetics of the channel suggest that it is part of the channel complex responsible for the sustained H+-activated cation current in sensory neurons that is thought to be important for the prolonged perception of pain that accompanies tissue acidosis (1, 2).
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