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Echovirus 30 Induced Neuronal Cell Death through TRIO-RhoA Signaling Activation

Figure 3

Echo30 infection induced TRIO-RhoA signaling activation in neuronal cell.

Human neuroblastoma SK-N-SH cells at 80% confluence were infected with Echo30 with 2% FBS contained MEM at 48 hrs. (A) Confirmation results of 2-DE using immunoblot blot analysis. TRIO protein expression was significantly increased in Echo30-infected SK-N-SH cells. (B) Immnoblot analysis for RhoA signaling. Echo30 infection induced activation of RhoA and RhoA targeted signaling in SK-N-SH cell. All data are representative of three independent experiments.

Figure 3

doi: https://doi.org/10.1371/journal.pone.0036656.g003