Review
doi: 10.1038/35024000.
Microtubule motors in mitosis
Affiliations
- PMID: 10993066
- DOI: 10.1038/35024000
Item in Clipboard
Review
Microtubule motors in mitosis
Nature.
.
Abstract
The mitotic spindle uses microtubule-based motor proteins to assemble itself and to segregate sister chromatids. It is becoming clear that motors invoke several distinct mechanisms to generate the forces that drive mitosis. Moreover, in carrying out its function, the spindle appears to pass through a series of transient steady-state structures, each established by a delicate balance of forces generated by multiple complementary and antagonistic motors. Transitions from one steady state to the next can occur when a change in the activity of a subset of mitotic motors tips the balance.
Similar articles
-
Cell biology. Serving up a plate of chromosomes.Science. 2006 Jan 20;311(5759):343-4. doi: 10.1126/science.1123525. Science. 2006. PMID: 16424328 No abstract available.
-
Mitotic microtubule crosslinkers: insights from mechanistic studies.Curr Biol. 2009 Dec 15;19(23):R1089-94. doi: 10.1016/j.cub.2009.10.047. Curr Biol. 2009. PMID: 20064413 Review.
-
Spindle microtubules: getting attached at both ends.Curr Biol. 2007 Nov 20;17(22):R966-9. doi: 10.1016/j.cub.2007.09.040. Curr Biol. 2007. PMID: 18029252 Review.
-
The mitotic spindle: a self-made machine.Science. 2001 Oct 19;294(5542):543-7. doi: 10.1126/science.1063488. Science. 2001. PMID: 11641489 Review.
-
The spindle: a dynamic assembly of microtubules and motors.Nat Cell Biol. 2001 Jan;3(1):E28-34. doi: 10.1038/35050669. Nat Cell Biol. 2001. PMID: 11146647 Review.
Cited by
-
A Ran-binding protein facilitates nuclear import of human papillomavirus type 16.PLoS Pathog. 2021 May 11;17(5):e1009580. doi: 10.1371/journal.ppat.1009580. eCollection 2021 May. PLoS Pathog. 2021. PMID: 33974675 Free PMC article.
-
Neck rotation and neck mimic docking in the noncatalytic Kar3-associated protein Vik1.J Biol Chem. 2012 Nov 23;287(48):40292-301. doi: 10.1074/jbc.M112.416529. Epub 2012 Oct 7. J Biol Chem. 2012. PMID: 23043140 Free PMC article.
-
Deletion of the Tail Domain of the Kinesin-5 Cin8 Affects Its Directionality.J Biol Chem. 2015 Jul 3;290(27):16841-50. doi: 10.1074/jbc.M114.620799. Epub 2015 May 19. J Biol Chem. 2015. PMID: 25991727 Free PMC article.
-
Silencing KIF18B enhances radiosensitivity: identification of a promising therapeutic target in sarcoma.EBioMedicine. 2020 Nov;61:103056. doi: 10.1016/j.ebiom.2020.103056. Epub 2020 Oct 7. EBioMedicine. 2020. PMID: 33038765 Free PMC article.
-
Roles of polymerization dynamics, opposed motors, and a tensile element in governing the length of Xenopus extract meiotic spindles.Mol Biol Cell. 2005 Jun;16(6):3064-76. doi: 10.1091/mbc.e05-02-0174. Epub 2005 Mar 23. Mol Biol Cell. 2005. PMID: 15788560 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
