Review
doi: 10.1016/0166-2236(94)90031-0.
Messenger plasticity in primary sensory neurons following axotomy and its functional implications
Affiliations
- PMID: 7511846
- DOI: 10.1016/0166-2236(94)90031-0
Item in Clipboard
Review
Messenger plasticity in primary sensory neurons following axotomy and its functional implications
Trends Neurosci.
1994 Jan.
Abstract
Following peripheral axotomy, long-lasting changes in the expression of neuropeptides and their receptors in primary sensory neurons are observed. These changes involve the downregulation of the excitatory peptides substance P and calcitonin gene-related peptide and the upregulation of the inhibitory peptides neuropeptide tyrosine and galanin, resulting in a reduction of transmission in the dorsal horn. The changes observed are thought to represent adaptive responses to limit the consequences of peripheral nerve damage to the organism as a whole and to promote survival and recovery of the individual neuron.
Comment in
-
VIP and messenger plasticity.Trends Neurosci. 1994 Aug;17(8):339. doi: 10.1016/0166-2236(94)90176-7. Trends Neurosci. 1994. PMID: 7526504 No abstract available.
Similar articles
-
Pituitary adenylate cyclase activating peptide expression in the rat dorsal root ganglia: up-regulation after peripheral nerve injury.Neuroscience. 1996 Oct;74(4):1099-110. doi: 10.1016/0306-4522(96)00168-6. Neuroscience. 1996. PMID: 8895878
-
Neuropeptides and neurotrophin receptor mRNAs in primary sensory neurons of aged rats.J Comp Neurol. 1996 Nov 11;375(2):303-19. doi: 10.1002/(SICI)1096-9861(19961111)375:23.0.CO;2-6. J Comp Neurol. 1996. PMID: 8915832
-
Inhibition of axoplasmic transport in the rat vagus nerve alters the numbers of neuropeptide and tyrosine hydroxylase messenger RNA-containing and immunoreactive visceral afferent neurons of the nodose ganglion.Neuroscience. 1995 May;66(1):175-87. doi: 10.1016/0306-4522(94)00561-i. Neuroscience. 1995. PMID: 7543661
-
Neuropeptide messenger plasticity in the CNS neurons following axotomy.Mol Neurobiol. 1995 Apr-Jun;10(2-3):91-103. doi: 10.1007/BF02740669. Mol Neurobiol. 1995. PMID: 7576312 Review.
-
Pituitary adenylate cyclase-activating polypeptide and islet amyloid polypeptide in primary sensory neurons: functional implications from plasticity in expression on nerve injury and inflammation.Mol Neurobiol. 1999 Jun;19(3):229-53. doi: 10.1007/BF02821715. Mol Neurobiol. 1999. PMID: 10495105 Review.
Cited by
-
Increased expression of Gem after rat sciatic nerve injury.J Mol Histol. 2013 Feb;44(1):27-36. doi: 10.1007/s10735-012-9459-2. Epub 2012 Oct 18. J Mol Histol. 2013. PMID: 23076376
-
Emerging role of Toll-like receptors in the control of pain and itch.Neurosci Bull. 2012 Apr;28(2):131-44. doi: 10.1007/s12264-012-1219-5. Neurosci Bull. 2012. PMID: 22466124 Free PMC article. Review.
-
Focal lysolecithin-induced demyelination of peripheral afferents results in neuropathic pain behavior that is attenuated by cannabinoids.J Neurosci. 2003 Apr 15;23(8):3221-33. doi: 10.1523/JNEUROSCI.23-08-03221.2003. J Neurosci. 2003. PMID: 12716929 Free PMC article.
-
Transcriptomics Analysis of Porcine Caudal Dorsal Root Ganglia in Tail Amputated Pigs Shows Long-Term Effects on Many Pain-Associated Genes.Front Vet Sci. 2019 Sep 18;6:314. doi: 10.3389/fvets.2019.00314. eCollection 2019. Front Vet Sci. 2019. PMID: 31620455 Free PMC article.
-
Release mode of large and small dense-core vesicles specified by different synaptotagmin isoforms in PC12 cells.Mol Biol Cell. 2011 Jul 1;22(13):2324-36. doi: 10.1091/mbc.E11-02-0159. Epub 2011 May 5. Mol Biol Cell. 2011. PMID: 21551071 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
