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HLA and Disease Associations

  • Book
  • © 1985

Overview

Authors:
  1. Jawahar L. Tiwari

    1. Center for The Health Sciences, UCLA Tissue Typing Laboratory, Los Angeles, USA

  2. Paul I. Terasaki

    1. UCLA Hospital and Clinics, Los Angeles, USA

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About this book

The human leukocyte antigen (HLA) or tissue types are the products of a rapidly developing field of knowledge within the last 20 years. In the early stages of the research many investigators suspected the existence of a complex series of transplantation antigens, but it was widely believed that these antigens would not be well-defined even in this century. Yet in the last two decades as many as 124 different HLA antigens determined by at least 7 very closely linked genes located on the short arm of chromosome 6 have been identified and subsequently agreed upon by an international nomenclature committee. 1 Extensive international collaboration fueled by the potential clinical application of these antigens to clinical transplantation has advanced the field rapidly. There were nine inter­ national histocompatibility workshops held during this period. Although iden­ tification of HLA antigens was of primary clinical importance in transplantation 2 and of great basic interest in human genetics and anthropology, a rather un­ expected bonus has been the determination that HLA antigens are associated with disease susceptibility to a greater extent than any other known genetic marker in man. In the past, many genetic polymorphisms have been suspected to be associated with diseases. The most extensively studied markers are blood groups, enzymes, and serum proteins. A comprehensive account of published studies, totalling approximately 1,000, of these markers is available in a book by Mourant et al.

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Table of contents (24 chapters)

  1. Front Matter

    Pages i-xxiii
    Download chapter PDF

  2. HLA Nomenclature

    • Jawahar L. Tiwari, Paul I. Terasaki
    Pages 1-3

  3. The HLA Complex

    • Jawahar L. Tiwari, Paul I. Terasaki
    Pages 4-17

  4. The Data and Statistical Analysis

    • Jawahar L. Tiwari, Paul I. Terasaki
    Pages 18-27

  5. Mechanisms of HLA and Disease Associations

    • Jawahar L. Tiwari, Paul I. Terasaki
    Pages 28-31

  6. Overview

    • Jawahar L. Tiwari, Paul I. Terasaki
    Pages 32-48

  7. Rheumatology and Joint Diseases

    • Jawahar L. Tiwari, Paul I. Terasaki
    Pages 49-111

  8. Dermatology

    • Jawahar L. Tiwari, Paul I. Terasaki
    Pages 112-151

  9. Neurology

    • Jawahar L. Tiwari, Paul I. Terasaki
    Pages 152-184

  10. Endocrinology

    • Jawahar L. Tiwari, Paul I. Terasaki
    Pages 185-231

  11. Gastroenterology

    • Jawahar L. Tiwari, Paul I. Terasaki
    Pages 232-263

  12. Ophthalmology

    • Jawahar L. Tiwari, Paul I. Terasaki
    Pages 264-276

  13. Malignancy

    • Jawahar L. Tiwari, Paul I. Terasaki
    Pages 277-321

  14. Allergy

    • Jawahar L. Tiwari, Paul I. Terasaki
    Pages 322-334

  15. Urogenital Diseases

    • Jawahar L. Tiwari, Paul I. Terasaki
    Pages 335-351

  16. Cardiovascular Diseases

    • Jawahar L. Tiwari, Paul I. Terasaki
    Pages 352-362

  17. Connective Tissue Diseases

    • Jawahar L. Tiwari, Paul I. Terasaki
    Pages 363-378

  18. Pulmonary Diseases

    • Jawahar L. Tiwari, Paul I. Terasaki
    Pages 379-382

  19. Infectious Diseases

    • Jawahar L. Tiwari, Paul I. Terasaki
    Pages 383-401

  20. Musculoskeletal Diseases

    • Jawahar L. Tiwari, Paul I. Terasaki
    Pages 402-403
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Authors and Affiliations

  • Center for The Health Sciences, UCLA Tissue Typing Laboratory, Los Angeles, USA

    Jawahar L. Tiwari

  • UCLA Hospital and Clinics, Los Angeles, USA

    Paul I. Terasaki

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Bibliographic Information

  • Book Title: HLA and Disease Associations

  • Authors: Jawahar L. Tiwari, Paul I. Terasaki

  • DOI: https://doi.org/10.1007/978-1-4613-8545-5

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag New York, Inc. 1985

  • Softcover ISBN: 978-1-4613-8547-9Published: 09 November 2011

  • eBook ISBN: 978-1-4613-8545-5Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: 472

  • Topics: Allergology, Immunology, Human Genetics

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