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Half a Century of In Vitro Fertilization

Reflections and Predictions

  • Book
  • © 2025

Overview

Editors:
  1. Yaakov Bentov

    1. Department of Obstetrics and Gynecology, Hadassah Mt. Scopus Jerusalem, Jerusalem, Israel

  2. Anat Hershko-Klement

    1. Department of Obstetrics and Gynecology, Hadassah Mt. Scopus Jerusalem, Jerusalem, Israel

  • Includes insights on the evolution of IVF by its pioneers
  • Provides foresight on the future of IVF based on current trends
  • Provides overview by leaders in each topic

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About this book

This book offers a historical perspective on the scientific milestones that have brought IVF to its current prominence and explores future directions based on ongoing research.

As we approach fifty years of IVF, this book reflects on the journey of a procedure that evolved from modest beginnings to a cornerstone of modern clinical care. Initially, years passed between successful pregnancies, but today, 2-4% of all births globally result from ART procedures. IVF stands out as one of the few medical interventions that effectively addressed the clinical problem it was designed to solve—sterility. Originally intended for women with blocked fallopian tubes, IVF soon revealed its potential to evaluate and manipulate oocytes and embryos, addressing a growing array of clinical needs.

This book will benefit professionals in the field of reproductive endocrinology and infertility and OBGYN as well as trainees. It may also be appealing the couples going through IVF treatments and the general public.  Readers may find in the book the historical origins of current day practice as well as and updated and future prospects.

 

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Table of contents (16 chapters)

  1. Front Matter

    Pages i-xi
    Download chapter PDF

  2. Foundations

    1. Front Matter

      Pages 1-1
      Download chapter PDF

    2. A Brief History of IVF

      • Yaakov Bentov, Joseph G. Schenker
      Pages 3-21

    3. History of Cryopreservation

      • Yaakov Bentov
      Pages 23-33

  3. History of IVF Related Pharma

    1. Front Matter

      Pages 35-35
      Download chapter PDF

    2. The Development and Current Role of Oral Fertility Medications Such as Clomiphene Citrate and Aromatase Inhibitors in IVF

      • Mohamed Mitwally, Robert F. Casper
      Pages 37-51

    3. The Evolution of Gonadotropins: Historical Review, Current Use, and a Look to the Future

      • Gil Gutvirtz, Eitan Lunenfeld
      Pages 53-68

    4. GnRH Antagonists and GnRH Agonists in Assisted Reproduction

      • Evangelia Deligeoroglou, Eleni Kolibianaki, Anastasia Moysiadou, Konstantina Pantazi, Efstratios Kolibianakis
      Pages 69-78

    5. IVF Protocols: Past, Present, and Future

      • Ranit Hizkiyahu, Einav Kadour Peero
      Pages 79-108

  4. Adunct Technologies

    1. Front Matter

      Pages 109-109
      Download chapter PDF

    2. History and Future in Male Infertility Treatment

      • Anat Hershko-Klement, Yaakov Bentov, Ranit Hizkiyahu
      Pages 111-120

    3. Morphology-Based Grading of Oocytes and Embryos

      • Azraa Janmohamed, Dan Nayot
      Pages 121-134

    4. Embryo Assessment: Preimplantation Genetic Testing (PGT)

      • Carmen Rubio, Daniela N. Bakalova, Xuhui Sun, Pere Mir
      Pages 135-157

  5. Future Predictions

    1. Front Matter

      Pages 159-159
      Download chapter PDF

    2. IVF in the Next Half a Century

      • Alan S. Penzias, Eli Y. Adashi
      Pages 161-167

    3. Global Trends in Infertility and Fecundity

      • Ranit Hizkiyahu, Anat Hershko-Klement, Yaakov Bentov
      Pages 169-191

    4. How Did Legislation Shape in Vitro Fertilization and Vice Versa, the Case of the Overturning of Roe V. Wade?

      • Yoav Stoler, Yaakov Bentov
      Pages 193-207

    5. Prenatal Assessment for Adult-Onset Diseases: Feasibility and Justifiability

      • Shirley Greenbaum, Keren Marks Garber, Anat Hershko-Klement, Yaakov Bentov
      Pages 209-224

    6. The Management of IVF Patients with Diminished Ovarian Reserve

      • Yaakov Bentov, Ilana Weizel
      Pages 225-262

    7. Germline Genomic Editing

      • Natalie Goldwicht, Hagit Daum
      Pages 263-273
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Editors and Affiliations

  • Department of Obstetrics and Gynecology, Hadassah Mt. Scopus Jerusalem, Jerusalem, Israel

    Yaakov Bentov, Anat Hershko-Klement

About the editors

Dr. Yaakov Bentov, MD, M.SC., Reproductive Endocrinology & Infertility Specialist (REI)

Dr. Yaakov Bentov earned his Medical Degree at Ben Gurion University in Israel. As a medical student, he founded a bachelor’s program in Emergency Medicine for paramedics, and later served as its Program Head. He had also pursued a master's degree in medical business administration (MBA) while completing his residency in Obstetrics Gynecology (1995-2002). Both programs were at Ben Gurion University.

After completing his residency, he came to Toronto to complete a fellowship in Reproductive Endocrinology and Infertility (REI) at the University of Toronto.

He later took the roles of medical director of the Ontario based Juno Fertility clinics as well as an associate REI & a research director at ANOVA fertility.

Dr. Bentov is an currently a senior REI in the Department of Obstetrics and Gynecology at Hadassah Mt. Scopus in Jerusalem. He pursues research in the areas of ovarian function and pathology, infertility, and reproductive endocrinology.

Dr. Bentov has published research in more than 70 peer reviewed publications and is an editor for several leading medical journals.


Anat Hershko Klement MD Reproductive Endocrinology & Infertility Specialist (REI)

Dr Anat Hershko-Klement completed her Obstetrics & Gynecology residency in 2010 and was later a postgraduate in reproductive endocrinology and infertility in Toronto. She is currently the head of the reproduction and IVF unit in Hadassah mount Scopus. Her special research interests are epidemiological aspects of ART and IVF pregnancy outcomes. She is involved in medical education and was leading the post-graduate school for reproductive endocrinology and infertility of the Israeli Fertility association between 2019-2022, as well as a member in the Israeli board exams in Obstetrics and Gynecology Dr. Hershko Klement has published 44 original articles , 23 of them as a principal investigator.



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Bibliographic Information

  • Book Title: Half a Century of In Vitro Fertilization

  • Book Subtitle: Reflections and Predictions

  • Editors: Yaakov Bentov, Anat Hershko-Klement

  • DOI: https://doi.org/10.1007/978-3-031-77255-9

  • Publisher: Springer Cham

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2025

  • Hardcover ISBN: 978-3-031-77254-2Published: 04 March 2025

  • Softcover ISBN: 978-3-031-77257-3Due: 18 March 2026

  • eBook ISBN: 978-3-031-77255-9Published: 03 March 2025

  • Edition Number: 1

  • Number of Pages: XI, 300

  • Number of Illustrations: 6 b/w illustrations, 15 illustrations in colour

  • Topics: Reproductive Medicine, Gynecology, Genetics and Genomics

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