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HIV Interactions with Host Cell Proteins

  • Book
  • © 2009

Overview

Editors:
  1. Paul Spearman

    1. School of Medicine, Dept. Pediatrics, Emory University, Atlanta, USA

  2. Eric O. Freed

    1. HIV Drug Resistance Program, National Cancer Institute-Frederick, Frederick, USA

Part of the book series: Current Topics in Microbiology and Immunology (CT MICROBIOLOGY, volume 339)

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About this book

The study of viruses necessarily involves dissecting the intimate details of cellular pathways. Viruses have often been employed as tools in studying cellular pathways, as was done by early retrovirologists such as Peyton Rous in attempting to understand the mechanism of cellular transformation and oncogenesis. On the other side of the coin, virologists seek to de?ne those cellular elements interacting intimatelywiththeir virus ofinterestinorder to better understand viral replication itself, and in some cases to develop antiviral strategies. It is in the intersection of virology and cell biology that many of us ?nd the most rewarding aspects of our research. When a new discovery yields insights into basic cellular mechanisms and presents new targets for int- vention to ?ght a serious pathogen, the impact can be high and the excitement intense. HIV has been no exception to the rule that viruses reveal many basic aspects of cellular biology. In recent years, in part because of the importance of HIV as a major cause of human suffering, numerous cellular processes have been elucidated through work on processes or proteins of this human retrovirus. The excitement in this ?eld is especially well illustrated by the discovery of new innate means of resisting viral replication, such as the work on APOBEC3G, TRIM5a, and BST-2/ tetherin presented in this volume.

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Table of contents (9 chapters)

  1. Front Matter

    Pages 1-9
    Download chapter PDF

  2. Host Restriction of HIV-1 by APOBEC3 and Viral Evasion Through Vif

    • Anna Maria Niewiadomska, Xiao-Fang Yu
    Pages 1-25

  3. Interactions of Viral protein U (Vpu) with Cellular Factors

    • John C. Guatelli
    Pages 27-45

  4. TRIM5alpha

    • Byeongwoon Song
    Pages 47-66

  5. Human Immunodeficiency Virus Type-1 Gag and Host Vesicular Trafficking Pathways

    • Hin Chu, Jaang-Jiun Wang, Paul Spearman
    Pages 67-84

  6. The Roles of Tetraspanins in HIV-1 Replication

    • Markus Thali
    Pages 85-102

  7. Imaging of HIV/Host Protein Interactions

    • Cindy M. Danielson, Thomas J. Hope
    Pages 103-123

  8. Virological and Cellular Roles of the Transcriptional Coactivator LEDGF/p75

    • Manuel Llano, James Morrison, Eric M. Poeschla
    Pages 125-146

  9. Implications of Nef: Host Cell Interactions in Viral Persistence and Progression to AIDS

    • Nathalie J. Arhel, Frank Kirchhoff
    Pages 147-175

  10. Vpr and Its Interactions with Cellular Proteins

    • Vicente Planelles, Serge Benichou
    Pages 177-200

  11. Back Matter

    Pages 1-4
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Editors and Affiliations

  • School of Medicine, Dept. Pediatrics, Emory University, Atlanta, USA

    Paul Spearman

  • HIV Drug Resistance Program, National Cancer Institute-Frederick, Frederick, USA

    Eric O. Freed

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Bibliographic Information

  • Book Title: HIV Interactions with Host Cell Proteins

  • Editors: Paul Spearman, Eric O. Freed

  • Series Title: Current Topics in Microbiology and Immunology

  • DOI: https://doi.org/10.1007/978-3-642-02175-6

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer-Verlag GmbH, DE, part of Springer Nature 2009

  • Hardcover ISBN: 978-3-642-02174-9Published: 15 December 2009

  • Softcover ISBN: 978-3-642-26182-4Published: 01 March 2012

  • eBook ISBN: 978-3-642-02175-6Published: 11 December 2009

  • Series ISSN: 0070-217X

  • Series E-ISSN: 2196-9965

  • Edition Number: 1

  • Number of Pages: X, 204

  • Number of Illustrations: 6 b/w illustrations, 20 illustrations in colour

  • Topics: Virology, Cancer Research

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