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LHRH and Its Analogs

Contraceptive and Therapeutic Applications Part 2

  • Book
  • © 1987

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Editors:
  1. B. H. Vickery
  2. J. J. Nestor

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About this book

Since the discovery of LHRH in 1971, research into the physiology and therapeutics of this compound can be divided into three dis­ tinctly different phases. In the first phase, attention was paid chiefly to the natural sequence hormone; efforts were channeled to explore its diagnostic use; and nearly all the clinical investigations were coordinated by a single pharmaceutical company. The successes in this area were quite limited and the interest in the promise of this agent as a diagnostic test has long since waned. This phase of research con­ sumed roughly the first seven years of clinical testing after the isolation and characterization of the compound by the two groups involved in the Nobel effort. With the appearance of long-acting LHRH agonists, the second phase of research on LHRH began in the late '70's. LHRH agonists were the only compounds available during this period of research and paradoxical desensitization was the predominant therapeutic basis for the discoveries. An ever-widening number of therapeutic applications using this approach were unearthed. A second theme which emerged during this second 5-7 year period was that the pulsatile administration of the natural sequence LHRH could be used to treat LHRH deficiency in men and women.

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Table of contents (38 chapters)

  1. Front Matter

    Pages i-xxiii
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  2. Chemistry

    1. Front Matter

      Pages 1-1
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    2. Development of LHRH Antagonists

      • J. J. Nestor Jr
      Pages 3-16

    3. LHRH Antagonists with Low Histamine Releasing Activity

      • R. W. Roeske, N. C. Chaturvedi, T. Hrinyo-Pavlina, M. Kowalczuk
      Pages 17-24

    4. Specificity of Design to Achieve Antagonists of LHRH of Increasing Effectiveness in Therapeutic Activity

      • K. Folkers, C. Bowers, P.-F. L. Tang, D. Feng, T. Okamoto, Y. Zhang et al.
      Pages 25-36

    5. Biosynthesis of LHRH

      • K. Nikolics, P. H. Seeburg
      Pages 37-51

    6. Phylogenetic Diversity of LHRH

      • J. A. King, R. P. Millar
      Pages 53-73

  3. Mechanisms of Action of Hypothalamic LHRH and Analogs

    1. Front Matter

      Pages 75-75
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    2. Molecular Mechanism of LHRH Action in the Gonadotrope

      • C. A. McArdle, P. M. Conn
      Pages 77-100

    3. Mediation of the Preovulatory LH Surge: LHRH Pulsatility and Opioid Modulation

      • A. L. Barkan, J. C. Marshall
      Pages 101-120

  4. Extra-Hypothalamic LHRH-Like Materials

    1. Front Matter

      Pages 121-121
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    2. LHRH Binding Sites in Human Tissues

      • T. A. Bramley
      Pages 123-139

    3. LHRH and “LHRH-Like” Factors in the Male Reproductive Tract

      • M. P. Hedger, D. M. Robertson, D. M. de Kretser
      Pages 141-160

    4. Placental LHRH-Like Activity

      • T. M. Siler-Khodr
      Pages 161-175

  5. Pharmacology of LHRH Antagonists

    1. Front Matter

      Pages 177-177
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    2. In Vitro Histamine Release with LHRH Analogs

      • M. J. Karten, W. A. Hook, R. P. Siraganian, D. H. Coy, K. Folkers, J. E. River et al.
      Pages 179-190

    3. Anaphylactoid Properties of LHRH Analogs

      • A. Phillips, D. W. Hahn, C. Bishop, R. J. Capetola, J. L. McGuire
      Pages 191-200

    4. Reproductive Physiology and General Pharmacology of LHRH Antagonists

      • B. H. Vickery
      Pages 201-215

    5. Suppression of Plasma Gonadotropins, Testosterone and Sperm Production in Adult Male Monkeys by a Potent Inhibitory Analog of LHRH

      • W. J. Bremner, L. A. Adams, R. A. Steiner
      Pages 217-225

    6. LHRH Antagonists and Female Reproductive Function

      • H. M. Fraser
      Pages 227-242
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Bibliographic Information

  • Book Title: LHRH and Its Analogs

  • Book Subtitle: Contraceptive and Therapeutic Applications Part 2

  • Editors: B. H. Vickery, J. J. Nestor

  • DOI: https://doi.org/10.1007/978-94-009-3229-6

  • Publisher: Springer Dordrecht

  • eBook Packages: Springer Book Archive

  • Copyright Information: MTP Press Limited 1987

  • Softcover ISBN: 978-94-010-7949-5Published: 03 November 2011

  • eBook ISBN: 978-94-009-3229-6Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: XXIII, 614

  • Topics: Gynecology

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