Specification and Plasticity of Mammalian Cochlear Hair Cell Progenitors

McGovern, Melissa M.; Groves, Andrew K.

doi:10.1007/978-3-031-20661-0_5

Part of the book series: Springer Handbook of Auditory Research ((SHAR,volume 75))

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Abstract

The mammalian cochlea detects and transduces auditory stimuli in the environment through sensory hair cells (HCs). Unlike non-mammalian species, mammalian cochlear HCs do not naturally regenerate after damage. This chapter describes the development of both HCs and their surrounding supporting cells (SCs) from common cochlear progenitor cells. SCs are of specific interest as they are proximal to the HCs, participate in HC regeneration in non-mammalian species, and are thus the best candidates for regenerative therapy. This chapter also discusses what is currently known about developmental signals that regulate the response of SCs to HC damage. Understanding the mechanisms that create both HCs and SCs will inform experimental design of regenerative therapies.

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Article Open access 11 May 2017

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Department of Neuroscience, Baylor College of Medicine, Houston, TX, USA
Melissa M. McGovern & Andrew K. Groves
Department of Human and Molecular Genetics, Baylor College of Medicine, Houston, TX, USA
Andrew K. Groves

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Melissa M. McGovern
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Andrew K. Groves
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Department of Otolaryngology, Washington University School of Medicine, St. Louis, MO, USA
Mark E. Warchol
Department of Otolaryngology/Head and Neck Surgery, Virginia Merrill Bloedel Hearing Research Center, University of Washington School of Medicine, Seattle, WA, USA
Jennifer S. Stone
Department of Integrative Physiology and Neuroscience, Washington State University, Vancouver, WA, USA
Allison B. Coffin
Department of Biology, University of Maryland, College Park, MD, USA
Arthur N. Popper
Department of Psychology, Loyola University Chicago, Chicago, IL, USA
Richard R. Fay

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McGovern, M.M., Groves, A.K. (2023). Specification and Plasticity of Mammalian Cochlear Hair Cell Progenitors. In: Warchol, M.E., Stone, J.S., Coffin, A.B., Popper, A.N., Fay, R.R. (eds) Hair Cell Regeneration. Springer Handbook of Auditory Research, vol 75. Springer, Cham. https://doi.org/10.1007/978-3-031-20661-0_5

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Published: 28 April 2023
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