Abstract
Susceptibility to a wide variety of human diseases is now strongly associated with genes within the human major histocompatibility complex (MHC). This complex, found on chromosome six, encodes three classes of molecules that are central to immunological function: class I (HLA-B, -C and the differentiation antigens TL and TQ), class II (HLA-DR, -DQ, -DP), and class III molecules (C2–C4 and BF). In addition to these molecules, other proteins are encoded by genes in this region.
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References
Association of Sleep Disorders Centers (1979) Diagnostic classification of sleep and arousal disorders, 1st edn. Prepared by the Sleep Disorders Classification Committee. Sleep 2: 1–137
Billiard M, Seignalet J (1985) Extraordinary association between HLA-DR2 and narcolepsy. Lancet I: 226–227
Honda Y, Asaka A, Tanaka A, Juji T (1983) Discrimination of narcoleptic patients using genetic markers and HLA. Sleep Res 12: 254
Juji T, Satake M, Honda Y, Doi Y (1984) HLA antigens in Japanese patients with narcolepsy. Tissue Antigens 24: 316–319
Langdon N. Welsh K, van Dam M, Vaugham RM, Parkes JD (1984) Genetic markers in narcolepsy. Lancet I: 226–227
Lilly F, Boyse EA, Old LJ (1964) Genetic basis for susceptibility to viral leukemogenesis. Lancet II: 1207–1209
Miles L (1983) Sleep questionnaire and assessment of wakefulness [SQAW]. In: Guilleminault C (ed) Sleeping and waking disorders: indications and techniques. Addison Wesley, Menlo Park, appendix
Mitler MM, Shafor R, Sobers M, Hajdukovich RM, Rubin RL (1986) Human leukocyte antigen [HLA] studies in excessive somnolence: narcolepsy vs. sleep apnea (abstract). Sleep Res 15
Neely SE, Rosenberg AS, Spire JP, Antel J, Arnasson BEW (1986) HLA, antigens in narcolepsy. Neurology 36 [Suppl I]: 299
Richardson G, Carskadon M, Flagg W, Van den Hoed J, Dement W, Mitler M (1982) Excessive daytime sleepiness in man: multiple sleep latency measurements in narcoleptics vs. control subjects. Electroencephalogr Clin Neurophysiol 45: 621–627
Stasny P, Ball EJ, Day PJ (1983) The human immune response region (HLA-D) and disease susceptibility. Immunol Rev 70: 113–152
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© 1988 Springer-Verlag Berlin Heidelberg
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Guilleminault, C. et al. (1988). HLA-DR2 and the Narcolepsy Syndrome: The Stanford Experience. In: Honda, Y., Juji, T. (eds) HLA in Narcolepsy. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-83387-8_8
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DOI: https://doi.org/10.1007/978-3-642-83387-8_8
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-83389-2
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