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Narcolepsy and HLA in the Federal Republic of Germany: Population and Family Data

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HLA in Narcolepsy

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Abstract

Fifty-nine unrelated narcolepsy patients as well as 14 families (01–14), including 16 patients and 44 healthy relatives, were investigated for MHC class I (HLA-A, B, C), class II (HLA-DR, DQ), and class III (BF, C4A, C4B) alleles. Glyoxalase-1 (GLO) was determined as an additional marker in family studies. For the population study, unrelated healthy individuals (class I, n=1329; class II, n=418; class III, n=408) served as normal controls. All methods used were described recently (Mueller-Eckhardt et al. 1986). Statistical evaluations were made with the X2 test with Yates’ correction. P-values were corrected for the number of antigens tested. Some of these results have been published elsewhere (Mueller-Eckhardt et al. 1986). They are presented here in more detail for comparison with data from other populations.

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References

  • Andreas-Zietz A, Keller E, Scholz S, Albert ED, Roth B, Nevsimalova S, Sonka K, Docekal P, Ivaskova E, Schulz H, Geisler P (1986) DR2-negative narcolepsy. Lancet II: 684–685

    Article  Google Scholar 

  • Billiard M, Seignalet J (1985) Extraordinary association between HLA-DR2 and narcolepsy. Lancet I: 226–227

    Article  Google Scholar 

  • Billiard M, Seignalet J, Besset A, Cadilhac J (1986) HLA-DR-2 and narcolepsy. Sleep 9: 149–152

    PubMed  CAS  Google Scholar 

  • Guilleminault C (1986) Narcolepsy 1985 (editorial). Sleep 9: 99–101

    PubMed  CAS  Google Scholar 

  • Honda Y, Asaka Y, Tanimura M, Furusho T (1983) A genetic study of narcolepsy and excessive daytime sleepiness in 308 families with a narcolepsy or hypersomnia proband. In: Guilleminault C, Lugaresi E (eds) Sleep wake disorders. Raven, New York

    Google Scholar 

  • Honda Y, Juji T, Matsuki K, Naohara T, Satake M, Inoko H, Someya T, Harada S, Doi Y (1986) HLA-DR2 and Dw2 in narcolepsy and in other disorders of excessive somnolence without cataplexy. Sleep 9: 133–142

    PubMed  CAS  Google Scholar 

  • Juji T, Satake M, Honda Y, Doi Y (1984) HLA antigens in Japanese patients with narcolepsy. Tissue antigens 24: 316–319

    Article  PubMed  CAS  Google Scholar 

  • Juji T, Matsuki K, Naohara T, Satake M, Honda Y (1985) Extraordinary association between HLA-DR2 and narcolepsy. Lancet I: 227

    Google Scholar 

  • Juji T, Honda Y, Matsuki K, Bashir H (1986) Narcolepsy: joint report. In: Aizawa M, Tatsri T, Wakiaka A, Konoeda Y (eds) Proc III Asia-Oceania histocompatibility workshop, Sapporo, 1986, pp 346–348

    Google Scholar 

  • Langdon N., Welsh K, van Dam M, Vaughan RW, Parkes D (1984) Genetic markers in narcolepsy. Lancet II: 1178–1180

    Article  Google Scholar 

  • Marcadet A, Gebuhrer L, Betuel H, Seignalet J, Freidel AC, Confavreux C, Billiard M, Dausset J, Cohen D (1985) DNA polymorphism related to HLA-DR2 Dw2 in patients with narcolepsy. Immunogenetics 22: 679–683

    Article  PubMed  CAS  Google Scholar 

  • Matsuki K, Juji T, Tokunaga K, Naohara T, Satake M., Honda Y (1985) Human histocompatibility leucocyte antigen (HLA) haplotype frequencies estimated from the data on HLA class I, II, and III, antigens in 111 Japanese narcoleptics. J Clin Invest 76: 2078–2083

    Article  PubMed  CAS  Google Scholar 

  • Meier-Ewert K (1983) Zur Begutachtung der Narkolepsien. Öff Gesundh Wes 45: 488–493

    CAS  Google Scholar 

  • Mueller-Eckhardt G, Meier-Ewert K, Schendel DJ, Reinecker FB, Multhoff G, Mueller-Eckhardt C (1986) HLA and narcolepsy in a German population. Tissue Antigens 28: 163–169

    Article  PubMed  CAS  Google Scholar 

  • Poirier G, Montplaisir J, Décary F, Momège D, Lebrun A (1986) HLA antigens in narcolepsy and idiopathic central nervous system hypersomnolence. Sleep 9: 153–158

    PubMed  CAS  Google Scholar 

  • Raynal D (1976) Polygraphic aspects of narcolepsy. In: Guilleminault C, Dement WC, Passouant P (eds) Narcolepsy. Spectrum, New York

    Google Scholar 

  • Seignalet J, Billiard M (1984) Possible association between HLA-B7 and narcolepsy. Tissue Antigens 23: 188–189

    Article  PubMed  CAS  Google Scholar 

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Authors
  1. K. Meier-Ewert
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  2. G. Mueller-Eckhardt
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  3. D. J. Schendel
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Editor information

Editors and Affiliations

  1. Neuropsychiatric Research Institute, Seiwa Hospital, 91 Bentencho, Shinjuku-ku, Tokyo, 162, Japan

    Yutaka Honda MD, DMedSc

  2. Blood Transfusion Service, Tokyo University Hospital, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113, Japan

    Takeo Juji MD, DMedSc

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© 1988 Springer-Verlag Berlin Heidelberg

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Meier-Ewert, K., Mueller-Eckhardt, G., Schendel, D.J. (1988). Narcolepsy and HLA in the Federal Republic of Germany: Population and Family Data. In: Honda, Y., Juji, T. (eds) HLA in Narcolepsy. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-83387-8_9

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  • DOI: https://doi.org/10.1007/978-3-642-83387-8_9

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-83389-2

  • Online ISBN: 978-3-642-83387-8

  • eBook Packages: Springer Book Archive

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