doi: 10.1016/s0092-8674(00)80655-8.
An endocytic pathway essential for renal uptake and activation of the steroid 25-(OH) vitamin D3
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- PMID: 10052453
- DOI: 10.1016/s0092-8674(00)80655-8
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An endocytic pathway essential for renal uptake and activation of the steroid 25-(OH) vitamin D3
Cell.
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Abstract
Steroid hormones may enter cells by diffusion through the plasma membrane. However, we demonstrate here that some steroid hormones are taken up by receptor-mediated endocytosis of steroid-carrier complexes. We show that 25-(OH) vitamin D3 in complex with its plasma carrier, the vitamin D-binding protein, is filtered through the glomerulus and reabsorbed in the proximal tubules by the endocytic receptor megalin. Endocytosis is required to preserve 25-(OH) vitamin D3 and to deliver to the cells the precursor for generation of 1,25-(OH)2 vitamin D3, a regulator of the calcium metabolism. Megalin-/- mice are unable to retrieve the steroid from the glomerular filtrate and develop vitamin D deficiency and bone disease.
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