Tumors of peripheral nerves: correlation of symptoms, clinical signs, imaging features, and histologic diagnosis
- PMID: 10384987
- DOI: 10.1007/s002560050498
Tumors of peripheral nerves: correlation of symptoms, clinical signs, imaging features, and histologic diagnosis
Abstract
Objective: To distinguish between benign and malignant tumors in the peripheral nerves.
Design and patients: The clinical, imaging and histologic findings of 99 benign and 16 malignant tumors in the peripheral nerves were reviewed retrospectively.
Results: Preoperative motor weakness was observed in only six of 99 benign tumors and was mild, while slight to severe motor weakness was present in 15 of 16 malignant lesions. Pain at rest was present in five of 99 benign tumors and in 15 of 16 malignant tumors. All benign lesions showed a smooth tumoral margin, while half the malignant lesions showed an invasive margin on CT or MRI. Thirteen of 28 benign lesions on CT and nine of 23 on MRI showed round to geographic central enhancement, but this pattern was not seen in malignant lesions.
Conclusion: Absence of severe motor weakness and a central enhancement pattern strongly suggest a benign nature, while severe rest pain and invasive tumor margin suggest malignant lesions in peripheral nerve tumors.
Similar articles
-
Differentiation of soft tissue benign and malignant peripheral nerve sheath tumors with magnetic resonance imaging.Clin Imaging. 2008 Mar-Apr;32(2):121-7. doi: 10.1016/j.clinimag.2007.05.006. Clin Imaging. 2008. PMID: 18313576
-
A 10-year review of benign and malignant peripheral nerve sheath tumors in a single center: clinical and radiographic features can help to differentiate benign from malignant lesions.Plast Reconstr Surg. 2008 Feb;121(2):529-533. doi: 10.1097/01.prs.0000297636.93164.cb. Plast Reconstr Surg. 2008. PMID: 18300972
-
Diagnosis of peripheral nerve sheath tumors around the pelvis.Jpn J Clin Oncol. 2004 Jul;34(7):405-13. doi: 10.1093/jjco/hyh072. Jpn J Clin Oncol. 2004. PMID: 15342668
-
Tumors and tumor-like lesions of peripheral nerves.Semin Musculoskelet Radiol. 2010 Nov;14(5):547-58. doi: 10.1055/s-0030-1268073. Epub 2010 Nov 11. Semin Musculoskelet Radiol. 2010. PMID: 21072731 Review.
-
An algorithmic approach to the management of peripheral nerve tumours.J Hand Surg Eur Vol. 2024 Jun;49(6):758-772. doi: 10.1177/17531934241238739. Epub 2024 Mar 27. J Hand Surg Eur Vol. 2024. PMID: 38534080 Review.
Cited by
-
State of the Art and Advances in Peripheral Nerve Surgery.Adv Tech Stand Neurosurg. 2022;45:245-283. doi: 10.1007/978-3-030-99166-1_8. Adv Tech Stand Neurosurg. 2022. PMID: 35976453 Review.
-
Benign Schwannoma Mimicking Metastatic Lesion on F-18 FDG PET/CT in Differentiated Thyroid Cancer.Nucl Med Mol Imaging. 2013 Jun;47(2):138-40. doi: 10.1007/s13139-013-0194-8. Epub 2013 Feb 22. Nucl Med Mol Imaging. 2013. PMID: 24900096 Free PMC article.
-
Median nerve schwannoma: A case and review of literature.Asian J Neurosurg. 2015 Jul-Sep;10(3):212-5. doi: 10.4103/1793-5482.161178. Asian J Neurosurg. 2015. PMID: 26396609 Free PMC article.
-
Soft-tissue masses in the shoulder girdle: an imaging perspective.Eur Radiol. 2007 Mar;17(3):768-83. doi: 10.1007/s00330-006-0220-7. Epub 2006 Apr 25. Eur Radiol. 2007. PMID: 16642327 Review.
-
Intramuscular ancient schwannoma of the axillary nerve.BMJ Case Rep. 2021 May 24;14(5):e239445. doi: 10.1136/bcr-2020-239445. BMJ Case Rep. 2021. PMID: 34031064 Free PMC article.
MeSH terms
LinkOut - more resources
Full Text Sources
