doi: 10.1126/science.285.5424.93.
Regulation of NMDA receptors by an associated phosphatase-kinase signaling complex
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- PMID: 10390370
- DOI: 10.1126/science.285.5424.93
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Regulation of NMDA receptors by an associated phosphatase-kinase signaling complex
Science.
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Abstract
Regulation of N-methyl-D-aspartate (NMDA) receptor activity by kinases and phosphatases contributes to the modulation of synaptic transmission. Targeting of these enzymes near the substrate is proposed to enhance phosphorylation-dependent modulation. Yotiao, an NMDA receptor-associated protein, bound the type I protein phosphatase (PP1) and the adenosine 3',5'-monophosphate (cAMP)-dependent protein kinase (PKA) holoenzyme. Anchored PP1 was active, limiting channel activity, whereas PKA activation overcame constitutive PP1 activity and conferred rapid enhancement of NMDA receptor currents. Hence, yotiao is a scaffold protein that physically attaches PP1 and PKA to NMDA receptors to regulate channel activity.
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