Localization of the tetrodotoxin-resistant sodium channel NaN in nociceptors
- PMID: 10683857
- DOI: 10.1097/00001756-200001170-00039
Localization of the tetrodotoxin-resistant sodium channel NaN in nociceptors
Abstract
Tetrodotoxin-resistant sodium currents contribute to the somal and axonal sodium currents of small diameter primary sensory neurons, many of which are nociceptive. NaN is a recently described tetrodotoxin-resistant sodium channel expressed preferentially in IB4-labeled dorsal root ganglion (DRG) neurons. We employed an antibody raised to a NaN specific peptide to show that NaN is preferentially localized along axons of IB4-positive unmyelinated fibers in the sciatic nerve and in axon terminals in the cornea. NaN immunoreactivity was also found at some nodes of Ranvier of thinly myelinated axons of the sciatic nerve, where it was juxtaposed to Kv1.2 potassium channel immunoreactivity. This distribution of NaN is consistent with a role for NaN sodium channels in nociceptive transmission.
Similar articles
-
Changes in expression of two tetrodotoxin-resistant sodium channels and their currents in dorsal root ganglion neurons after sciatic nerve injury but not rhizotomy.J Neurosci. 2000 Oct 1;20(19):7279-89. doi: 10.1523/JNEUROSCI.20-19-07279.2000. J Neurosci. 2000. PMID: 11007885 Free PMC article.
-
Contactin regulates the current density and axonal expression of tetrodotoxin-resistant but not tetrodotoxin-sensitive sodium channels in DRG neurons.Eur J Neurosci. 2005 Jul;22(1):39-49. doi: 10.1111/j.1460-9568.2005.04186.x. Eur J Neurosci. 2005. PMID: 16029194
-
Differential role of GDNF and NGF in the maintenance of two TTX-resistant sodium channels in adult DRG neurons.Brain Res Mol Brain Res. 1999 Apr 20;67(2):267-82. doi: 10.1016/s0169-328x(99)00070-4. Brain Res Mol Brain Res. 1999. PMID: 10216225
-
NaN/Nav1.9: a sodium channel with unique properties.Trends Neurosci. 2002 May;25(5):253-9. doi: 10.1016/s0166-2236(02)02150-1. Trends Neurosci. 2002. PMID: 11972962 Review.
-
Distribution of the tetrodotoxin-resistant sodium channel PN3 in rat sensory neurons in normal and neuropathic conditions.J Neurosci. 1998 Mar 15;18(6):2174-87. doi: 10.1523/JNEUROSCI.18-06-02174.1998. J Neurosci. 1998. PMID: 9482802 Free PMC article. Review.
Cited by
-
Changes in expression of two tetrodotoxin-resistant sodium channels and their currents in dorsal root ganglion neurons after sciatic nerve injury but not rhizotomy.J Neurosci. 2000 Oct 1;20(19):7279-89. doi: 10.1523/JNEUROSCI.20-19-07279.2000. J Neurosci. 2000. PMID: 11007885 Free PMC article.
-
betaIV spectrin, a new spectrin localized at axon initial segments and nodes of ranvier in the central and peripheral nervous system.J Cell Biol. 2000 Nov 27;151(5):985-1002. doi: 10.1083/jcb.151.5.985. J Cell Biol. 2000. PMID: 11086001 Free PMC article.
-
Endothelin-1 (ET-1) selectively enhances the activation gating of slowly inactivating tetrodotoxin-resistant sodium currents in rat sensory neurons: a mechanism for the pain-inducing actions of ET-1.J Neurosci. 2002 Aug 1;22(15):6325-30. doi: 10.1523/JNEUROSCI.22-15-06325.2002. J Neurosci. 2002. PMID: 12151509 Free PMC article.
-
Roles of tetrodotoxin (TTX)-sensitive Na+ current, TTX-resistant Na+ current, and Ca2+ current in the action potentials of nociceptive sensory neurons.J Neurosci. 2002 Dec 1;22(23):10277-90. doi: 10.1523/JNEUROSCI.22-23-10277.2002. J Neurosci. 2002. PMID: 12451128 Free PMC article.
-
The presence and role of the tetrodotoxin-resistant sodium channel Na(v)1.9 (NaN) in nociceptive primary afferent neurons.J Neurosci. 2002 Sep 1;22(17):7425-33. doi: 10.1523/JNEUROSCI.22-17-07425.2002. J Neurosci. 2002. PMID: 12196564 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Molecular Biology Databases
