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. 2000 Jun;155(2):945-59.
doi: 10.1093/genetics/155.2.945.

Inference of population structure using multilocus genotype data

J K Pritchard  1 , M Stephens, P Donnelly
Affiliations

Inference of population structure using multilocus genotype data

J K Pritchard et al. Genetics. 2000 Jun.

Abstract

We describe a model-based clustering method for using multilocus genotype data to infer population structure and assign individuals to populations. We assume a model in which there are K populations (where K may be unknown), each of which is characterized by a set of allele frequencies at each locus. Individuals in the sample are assigned (probabilistically) to populations, or jointly to two or more populations if their genotypes indicate that they are admixed. Our model does not assume a particular mutation process, and it can be applied to most of the commonly used genetic markers, provided that they are not closely linked. Applications of our method include demonstrating the presence of population structure, assigning individuals to populations, studying hybrid zones, and identifying migrants and admixed individuals. We show that the method can produce highly accurate assignments using modest numbers of loci-e.g. , seven microsatellite loci in an example using genotype data from an endangered bird species. The software used for this article is available from http://www.stats.ox.ac.uk/ approximately pritch/home. html.

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References

    1. Nature. 1994 Mar 31;368(6470):455-7 - PubMed
    1. Trends Ecol Evol. 1999 Jan;14(1):17-21 - PubMed
    1. Proc Natl Acad Sci U S A. 1997 Aug 19;94(17):9197-201 - PubMed
    1. J Hered. 1997 Sep-Oct;88(5):335-42 - PubMed
    1. Mol Ecol. 1995 Jun;4(3):347-54 - PubMed

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