Pain genes?: natural variation and transgenic mutants
- PMID: 10845081
- DOI: 10.1146/annurev.neuro.23.1.777
Pain genes?: natural variation and transgenic mutants
Abstract
Like many other complex biological phenomena, pain is starting to be studied at the level of the gene. Advances in molecular biological technology have allowed the cloning, mapping, and sequencing of genes, and also the ability to disrupt their function entirely (i.e. via transgenic knockouts). With these new tools at hand, pain researchers have begun in earnest the task of defining (a) which of the 70,000-150,000 mammalian genes are involved in the mediation of pain, and (b) which of the pain-relevant genes are polymorphic, contributing to both natural variation in responses and pathology. Although there are only a few known examples in which single gene mutations in humans are associated with pain conditions (e.g. an inherited form of migraine and congenital insensitivity to pain), it is likely that others will be identified. Concurrently, a variety of genes have been implicated in both the transmission and control of "pain" messages in animals. The present review summarizes current progress to these ends, focusing on both transgenic (gene-->behavior) and classical genetic (behavior-->gene) approaches in both humans and laboratory mice.
Similar articles
-
Transgenic studies of pain and analgesia: mutation or background genotype?J Pharmacol Exp Ther. 2001 May;297(2):467-73. J Pharmacol Exp Ther. 2001. PMID: 11303031 Review.
-
The Pain Genes Database: An interactive web browser of pain-related transgenic knockout studies.Pain. 2007 Sep;131(1-2):3.e1-4. doi: 10.1016/j.pain.2007.04.041. Epub 2007 Jun 14. Pain. 2007. PMID: 17574758 Review.
-
The molecular genetic basis and diagnosis of familial hypercholesterolemia in Denmark.Dan Med Bull. 2002 Nov;49(4):318-45. Dan Med Bull. 2002. PMID: 12553167 Review.
-
Gene-based approaches in pain research and exploration of new therapeutic targets and strategies.Eur J Pharmacol. 2013 Sep 15;716(1-3):129-41. doi: 10.1016/j.ejphar.2013.01.073. Epub 2013 Mar 13. Eur J Pharmacol. 2013. PMID: 23500201 Review.
-
[Posttraumatic stress disorder (PTSD) as a consequence of the interaction between an individual genetic susceptibility, a traumatogenic event and a social context].Encephale. 2012 Oct;38(5):373-80. doi: 10.1016/j.encep.2011.12.003. Epub 2012 Jan 24. Encephale. 2012. PMID: 23062450 Review. French.
Cited by
-
Catecholaminergic and opioidergic system mediated effects of reboxetine on diabetic neuropathic pain.Psychopharmacology (Berl). 2020 Apr;237(4):1131-1145. doi: 10.1007/s00213-019-05443-5. Epub 2020 Jan 7. Psychopharmacology (Berl). 2020. PMID: 31912189
-
Chronic pain disorders and headache chronification.Curr Pain Headache Rep. 2009 Aug;13(4):308-13. doi: 10.1007/s11916-009-0049-2. Curr Pain Headache Rep. 2009. PMID: 19586595 Review.
-
Pain genes.PLoS Genet. 2008 Jul 25;4(7):e1000086. doi: 10.1371/journal.pgen.1000086. PLoS Genet. 2008. PMID: 18654615 Free PMC article. Review.
-
Sex-based differences in pain perception and treatment.Pain Med. 2009 Mar;10(2):289-99. doi: 10.1111/j.1526-4637.2008.00558.x. Epub 2009 Jan 16. Pain Med. 2009. PMID: 19207233 Free PMC article. Review.
-
Essential function of oncostatin m in nociceptive neurons of dorsal root ganglia.J Neurosci. 2004 Feb 25;24(8):1941-7. doi: 10.1523/JNEUROSCI.4975-03.2004. J Neurosci. 2004. PMID: 14985435 Free PMC article.
Publication types
MeSH terms
Grants and funding
LinkOut - more resources
Full Text Sources
Medical
