Chemotherapy-induced peripheral neurotoxicity and complementary and alternative medicines: progress and perspective
- PMID: 26557088
- PMCID: PMC4615942
- DOI: 10.3389/fphar.2015.00234
Chemotherapy-induced peripheral neurotoxicity and complementary and alternative medicines: progress and perspective
Abstract
Chemotherapy-induced peripheral neurotoxicity (CIPN) is a severe and dose-limiting side effect of antineoplastic drugs. It can cause sensory, motor and autonomic system dysfunction, and ultimately force patients to discontinue chemotherapy. Until now, little is understood about CIPN and no consistent caring standard is available. Since CIPN is a multifactorial disease, the clinical efficacy of single pharmacological drugs is disappointing, prompting patients to seek alternative treatment options. Complementary and alternative medicines (CAMs), especially herbal medicines, are well known for their multifaceted implications and widely used in human health care. Up to date, several phytochemicals, plant extractions, and herbal formulas have been evaluated for their potential therapeutic benefit of preventing the onset and progression of CIPN in experimental models. Clinical acupuncture has also been shown to improve CIPN symptoms. In this review, we will give an outline of our current knowledge regrading the advanced research of CIPN, the role of CAMs in alleviating CIPN and possible lacunae in research that needs to be addressed.
Keywords: Pathogenesis; acupuncture; chemotherapy-induced peripheral neurotoxicity; complementary and alternative medicine; herbal medicine.
Figures
Similar articles
-
Therapeutic Effects of Phytochemicals and Medicinal Herbs on Chemotherapy-Induced Peripheral Neuropathy.Molecules. 2016 Sep 20;21(9):1252. doi: 10.3390/molecules21091252. Molecules. 2016. PMID: 27657026 Free PMC article. Review.
-
Chemotherapy-induced peripheral neurotoxicity.Curr Opin Neurol. 2015 Oct;28(5):500-7. doi: 10.1097/WCO.0000000000000234. Curr Opin Neurol. 2015. PMID: 26197027 Review.
-
Prevention and Management of Chemotherapy-Induced Polyneuropathy.Breast Care (Basel). 2019 Apr;14(2):79-84. doi: 10.1159/000499599. Epub 2019 Apr 10. Breast Care (Basel). 2019. PMID: 31798378 Free PMC article. Review.
-
Herbal medicines and chemotherapy induced peripheral neuropathy (CIPN): A critical literature review.Crit Rev Food Sci Nutr. 2017 Apr 13;57(6):1107-1118. doi: 10.1080/10408398.2014.889081. Crit Rev Food Sci Nutr. 2017. PMID: 25849070 Review.
-
A review of complementary therapies with medicinal plants for chemotherapy-induced peripheral neuropathy.Complement Ther Med. 2019 Feb;42:226-232. doi: 10.1016/j.ctim.2018.11.022. Epub 2018 Nov 27. Complement Ther Med. 2019. PMID: 30670246 Review.
Cited by
-
Incidence and correlates of high-grade chemotherapy-induced peripheral neuropathy in patients with lung cancer.Oncologist. 2025 Mar 10;30(3):oyaf036. doi: 10.1093/oncolo/oyaf036. Oncologist. 2025. PMID: 40152312 Free PMC article.
-
Application Potential of Plant-Derived Medicines in Prevention and Treatment of Platinum-Induced Peripheral Neurotoxicity.Front Pharmacol. 2022 Jan 13;12:792331. doi: 10.3389/fphar.2021.792331. eCollection 2021. Front Pharmacol. 2022. PMID: 35095502 Free PMC article. Review.
-
The gut microbiota-neuroimmune crosstalk and neuropathic pain: a scoping review.Gut Microbiome (Camb). 2023 Jun 19;4:e10. doi: 10.1017/gmb.2023.7. eCollection 2023. Gut Microbiome (Camb). 2023. PMID: 39295900 Free PMC article.
-
Editor's Highlight: Multiparametric Image Analysis of Rat Dorsal Root Ganglion Cultures to Evaluate Peripheral Neuropathy-Inducing Chemotherapeutics.Toxicol Sci. 2017 Mar 1;156(1):275-288. doi: 10.1093/toxsci/kfw254. Toxicol Sci. 2017. PMID: 28115644 Free PMC article.
-
Evidence, safety and recommendations for when to use acupuncture for treating cancer related symptoms: a narrative review.Integr Med Res. 2019 Sep;8(3):160-166. doi: 10.1016/j.imr.2019.05.002. Epub 2019 May 17. Integr Med Res. 2019. PMID: 31304088 Free PMC article. Review.
References
-
- Ameyaw E. O., Woode E., Boakye-Gyasi E., Abotsi W. K., Kyekyeku J. O., Adosraku R. K. (2014). Anti-allodynic and Anti-hyperalgesic effects of an ethanolic extract and xylopic acid from the fruits of Xylopia aethiopica in murine models of neuropathic pain. Pharmacognosy Res. 6 172–179. 10.4103/0974-8490.129041 - DOI - PMC - PubMed
Publication types
LinkOut - more resources
Full Text Sources
Other Literature Sources