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Clinical Trial
. 2001 Jun;81(3):433-5.
doi: 10.1006/gyno.2001.6182.

A phase II trial of CI-958 in recurrent platinum-sensitive ovarian carcinoma: a Gynecologic Oncology Group study

M A Hoffman  1 , J A Blessing, E R Nuñez
Affiliations
Clinical Trial

A phase II trial of CI-958 in recurrent platinum-sensitive ovarian carcinoma: a Gynecologic Oncology Group study

M A Hoffman et al. Gynecol Oncol. 2001 Jun.

Abstract

Objectives: To estimate the antitumor efficacy of CI-958 in patients with measurable recurrences of platinum-sensitive ovarian carcinoma and to determine the nature and degree of toxicity of CI-958 in these patients.

Methods: Patients received CI-958 560 mg/m2 intravenously every 3 weeks and tumor measurements were performed every one to two cycles.

Results: Of 23 patients entered in the study, there was one complete response and 10 patients had stable disease with short response durations.

Conclusions: CI-958 has minimal activity in recurrent platinum-sensitive ovarian carcinoma at the dose and schedule tested.

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