doi: 10.1038/ng848.
Epub 2002 Feb 19.
Beethoven, a mouse model for dominant, progressive hearing loss DFNA36
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- PMID: 11850623
- DOI: 10.1038/ng848
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Beethoven, a mouse model for dominant, progressive hearing loss DFNA36
Nat Genet.
2002 Mar.
Abstract
Despite recent progress in identifying genes underlying deafness, there are still relatively few mouse models of specific forms of human deafness. Here we describe the phenotype of the Beethoven (Bth) mouse mutant and a missense mutation in Tmc1 (transmembrane cochlear-expressed gene 1). Progressive hearing loss (DFNA36) and profound congenital deafness (DFNB7/B11) are caused by dominant and recessive mutations of the human ortholog, TMC1 (ref. 1), for which Bth and deafness (dn) are mouse models, respectively.
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