Review
doi: 10.1016/s0968-0004(02)02154-0.
TRAM, LAG1 and CLN8: members of a novel family of lipid-sensing domains?
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- PMID: 12151215
- DOI: 10.1016/s0968-0004(02)02154-0
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Review
TRAM, LAG1 and CLN8: members of a novel family of lipid-sensing domains?
Trends Biochem Sci.
2002 Aug.
Abstract
A family of membrane-associated proteins related to yeast Lag1p and mammalian TRAM has been identified. The family includes the protein product of CLN8, a gene mutated in progressive epilepsy with mental retardation. Mouse CLN8 is also mutated in the mnd/mnd mouse, a model for neuronal ceroid lipofuscinoses. The identification of these homologues has potential implications for our understanding of ceramide synthesis, lipid regulation and protein translocation in the endoplasmic reticulum.
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