TRAM, LAG1 and CLN8: members of a novel family of lipid-sensing domains?
- PMID: 12151215
- DOI: 10.1016/s0968-0004(02)02154-0
TRAM, LAG1 and CLN8: members of a novel family of lipid-sensing domains?
Abstract
A family of membrane-associated proteins related to yeast Lag1p and mammalian TRAM has been identified. The family includes the protein product of CLN8, a gene mutated in progressive epilepsy with mental retardation. Mouse CLN8 is also mutated in the mnd/mnd mouse, a model for neuronal ceroid lipofuscinoses. The identification of these homologues has potential implications for our understanding of ceramide synthesis, lipid regulation and protein translocation in the endoplasmic reticulum.
Similar articles
-
Two endoplasmic reticulum (ER) membrane proteins that facilitate ER-to-Golgi transport of glycosylphosphatidylinositol-anchored proteins.Mol Biol Cell. 1999 Apr;10(4):1043-59. doi: 10.1091/mbc.10.4.1043. Mol Biol Cell. 1999. PMID: 10198056 Free PMC article.
-
The neuronal ceroid lipofuscinoses in human EPMR and mnd mutant mice are associated with mutations in CLN8.Nat Genet. 1999 Oct;23(2):233-6. doi: 10.1038/13868. Nat Genet. 1999. PMID: 10508524
-
The neuronal ceroid lipofuscinosis CLN8 membrane protein is a resident of the endoplasmic reticulum.Hum Mol Genet. 2000 Jul 1;9(11):1691-7. doi: 10.1093/hmg/9.11.1691. Hum Mol Genet. 2000. PMID: 10861296
-
[The mechanisms of endoplasmic reticulum protein localization by vesicle recycling].Seikagaku. 1998 Dec;70(12):1387-400. Seikagaku. 1998. PMID: 10025160 Review. Japanese. No abstract available.
-
LAG1 puts the focus on ceramide signaling.Int J Biochem Cell Biol. 2002 Nov;34(11):1491-5. doi: 10.1016/s1357-2725(02)00044-4. Int J Biochem Cell Biol. 2002. PMID: 12200041 Review.
Cited by
-
Acyl chain specificity of ceramide synthases is determined within a region of 150 residues in the Tram-Lag-CLN8 (TLC) domain.J Biol Chem. 2012 Jan 27;287(5):3197-206. doi: 10.1074/jbc.M111.280271. Epub 2011 Dec 5. J Biol Chem. 2012. PMID: 22144673 Free PMC article.
-
Interactions of the proteins of neuronal ceroid lipofuscinosis: clues to function.Cell Mol Life Sci. 2011 Feb;68(3):453-74. doi: 10.1007/s00018-010-0468-6. Epub 2010 Aug 1. Cell Mol Life Sci. 2011. PMID: 20680390 Free PMC article. Review.
-
Correlations between genotype, ultrastructural morphology and clinical phenotype in the neuronal ceroid lipofuscinoses.Neurogenetics. 2005 Sep;6(3):107-26. doi: 10.1007/s10048-005-0218-3. Epub 2005 Sep 28. Neurogenetics. 2005. PMID: 15965709 Review.
-
Membrane fluidity is regulated by the C. elegans transmembrane protein FLD-1 and its human homologs TLCD1/2.Elife. 2018 Dec 4;7:e40686. doi: 10.7554/eLife.40686. Elife. 2018. PMID: 30509349 Free PMC article.
-
Ceramide synthases at the centre of sphingolipid metabolism and biology.Biochem J. 2012 Feb 1;441(3):789-802. doi: 10.1042/BJ20111626. Biochem J. 2012. PMID: 22248339 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Molecular Biology Databases