Review
doi: 10.1038/nrd961.
The use and analysis of microarray data
Affiliations
- PMID: 12461517
- DOI: 10.1038/nrd961
Item in Clipboard
Review
The use and analysis of microarray data
Nat Rev Drug Discov.
2002 Dec.
Abstract
Functional genomics is the study of gene function through the parallel expression measurements of genomes, most commonly using the technologies of microarrays and serial analysis of gene expression. Microarray usage in drug discovery is expanding, and its applications include basic research and target discovery, biomarker determination, pharmacology, toxicogenomics, target selectivity, development of prognostic tests and disease-subclass determination. This article reviews the different ways to analyse large sets of microarray data, including the questions that can be asked and the challenges in interpreting the measurements.
Similar articles
-
Designer genes: Filling the gap in transplantation.Transplantation. 2006 Nov 27;82(10):1261-72. doi: 10.1097/01.tp.0000229436.89345.d0. Transplantation. 2006. PMID: 17130773 Review.
-
Microarray expression profiling: analysis and applications.Curr Opin Drug Discov Devel. 2003 May;6(3):384-95. Curr Opin Drug Discov Devel. 2003. PMID: 12833672 Review.
-
DNA microarray experiments: biological and technological aspects.Biometrics. 2002 Dec;58(4):701-17. doi: 10.1111/j.0006-341x.2002.00701.x. Biometrics. 2002. PMID: 12495124 Review.
-
[Functional genomics analysis on DNA microarray].Tanpakushitsu Kakusan Koso. 2004 Aug;49(11 Suppl):1853-8. Tanpakushitsu Kakusan Koso. 2004. PMID: 15377028 Review. Japanese. No abstract available.
-
Improving reliability and performance of DNA microarrays.Expert Rev Mol Diagn. 2006 May;6(3):481-92. doi: 10.1586/14737159.6.3.481. Expert Rev Mol Diagn. 2006. PMID: 16706748 Review.
Cited by
-
Genomics and proteomics: role in the management of multiple sclerosis.J Neurol. 2005 Sep;252 Suppl 3:iii21-iii27. doi: 10.1007/s00415-005-2013-3. J Neurol. 2005. PMID: 16170496 Review.
-
Genome-wide estimation of transcript concentrations from spotted cDNA microarray data.Nucleic Acids Res. 2005 Oct 4;33(17):e143. doi: 10.1093/nar/gni141. Nucleic Acids Res. 2005. PMID: 16204447 Free PMC article.
-
Genomics for weed science.Curr Genomics. 2010 Mar;11(1):47-51. doi: 10.2174/138920210790217972. Curr Genomics. 2010. PMID: 20808523 Free PMC article.
-
MicroRNA profiling reveals distinct signatures in B cell chronic lymphocytic leukemias.Proc Natl Acad Sci U S A. 2004 Aug 10;101(32):11755-60. doi: 10.1073/pnas.0404432101. Epub 2004 Jul 29. Proc Natl Acad Sci U S A. 2004. PMID: 15284443 Free PMC article.
-
Comparative study of unsupervised dimension reduction techniques for the visualization of microarray gene expression data.BMC Bioinformatics. 2010 Nov 18;11:567. doi: 10.1186/1471-2105-11-567. BMC Bioinformatics. 2010. PMID: 21087509 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
