The ups and downs of Gs- to Gi-protein switching

doi:10.1038/sj.bjp.0705192

Editorial

. 2003 Apr;138(7):1188-9.

doi: 10.1038/sj.bjp.0705192.

The ups and downs of Gs- to Gi-protein switching

Stephen J Hill¹, Jillian G Baker

Affiliations

PMID: 12711616
PMCID: PMC1573788
DOI: 10.1038/sj.bjp.0705192

Editorial

The ups and downs of Gs- to Gi-protein switching

Stephen J Hill et al. Br J Pharmacol. 2003 Apr.

. 2003 Apr;138(7):1188-9.

doi: 10.1038/sj.bjp.0705192.

Authors

Stephen J Hill¹, Jillian G Baker

Affiliation

¹ Institute of Cell Signalling, Medical School, Queen's Medical Centre, Nottingham NG7 2UH. [email protected]

PMID: 12711616
PMCID: PMC1573788
DOI: 10.1038/sj.bjp.0705192

No abstract available

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Comment on

Cardiac-specific overexpression of human beta2 adrenoceptors in mice exposes coupling to both Gs and Gi proteins.
Hasseldine AR, Harper EA, Black JW. Hasseldine AR, et al. Br J Pharmacol. 2003 Apr;138(7):1358-66. doi: 10.1038/sj.bjp.0705191. Br J Pharmacol. 2003. PMID: 12711637 Free PMC article.

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References

1. BOND R.A., LEFF P., JOHNSON T.D., MILANO C.A., ROCKMAN H.A., MCMINN T.R., APPARSUNDARAM S., HYEK M.F., KENAKIN T.P., ALLEN L.F., LEFKOWITZ R.J. Physiological effects of inverse agonists in transgenic mice with myocardial overexpression of the beta 2-adrenoceptor. Nature. 1995;374:272–276. - PubMed
1. DAAKA Y., LUTTRELL L.M., LEFKOWITZ R.J. Switching of the coupling of the beta 2-adrenergic receptor to different G-proteins by protein kinase A. Nature. 1997;390:88–91. - PubMed
1. FRIEDMAN J., BABU B., CLARK R.B. β2-adrenergic receptor lacking the cyclic AMP-dependent protein kinase consensus sites fully activates extracellular signal-regulated kinase 1/2 in human embryonic kidney 293 cells: lack of evidence for GS/Gi switching. Mol. Pharmacol. 2002;62:1094–1102. - PubMed
1. HASSELDINE A.R.G., HARPER E.A., BLACK J.W. Cardiac-specific overexpression of human β2-adrenoceptors in mice exposes coupling to both Gs and Gi proteins. Br. J. Pharmacol. 2003;138:1361–1369. - PMC - PubMed
1. KILTS J.D., AKAZAWA T., RICHARDSON M.D., KWATRA M.M. Age increases cardiac Gαi2 expression, resulting in enhanced coupling to G protein-coupled receptors. J. Biol. Chem. 2002;277:31257–31262. - PubMed

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[1] BOND R.A., LEFF P., JOHNSON T.D., MILANO C.A., ROCKMAN H.A., MCMINN T.R., APPARSUNDARAM S., HYEK M.F., KENAKIN T.P., ALLEN L.F., LEFKOWITZ R.J. Physiological effects of inverse agonists in transgenic mice with myocardial overexpression of the beta 2-adrenoceptor. Nature. 1995;374:272–276. - PubMed

[2] BOND R.A., LEFF P., JOHNSON T.D., MILANO C.A., ROCKMAN H.A., MCMINN T.R., APPARSUNDARAM S., HYEK M.F., KENAKIN T.P., ALLEN L.F., LEFKOWITZ R.J. Physiological effects of inverse agonists in transgenic mice with myocardial overexpression of the beta 2-adrenoceptor. Nature. 1995;374:272–276. - PubMed

[3] DAAKA Y., LUTTRELL L.M., LEFKOWITZ R.J. Switching of the coupling of the beta 2-adrenergic receptor to different G-proteins by protein kinase A. Nature. 1997;390:88–91. - PubMed

[4] DAAKA Y., LUTTRELL L.M., LEFKOWITZ R.J. Switching of the coupling of the beta 2-adrenergic receptor to different G-proteins by protein kinase A. Nature. 1997;390:88–91. - PubMed

[5] FRIEDMAN J., BABU B., CLARK R.B. β2-adrenergic receptor lacking the cyclic AMP-dependent protein kinase consensus sites fully activates extracellular signal-regulated kinase 1/2 in human embryonic kidney 293 cells: lack of evidence for GS/Gi switching. Mol. Pharmacol. 2002;62:1094–1102. - PubMed

[6] FRIEDMAN J., BABU B., CLARK R.B. β2-adrenergic receptor lacking the cyclic AMP-dependent protein kinase consensus sites fully activates extracellular signal-regulated kinase 1/2 in human embryonic kidney 293 cells: lack of evidence for GS/Gi switching. Mol. Pharmacol. 2002;62:1094–1102. - PubMed

[7] HASSELDINE A.R.G., HARPER E.A., BLACK J.W. Cardiac-specific overexpression of human β2-adrenoceptors in mice exposes coupling to both Gs and Gi proteins. Br. J. Pharmacol. 2003;138:1361–1369. - PMC - PubMed

[8] HASSELDINE A.R.G., HARPER E.A., BLACK J.W. Cardiac-specific overexpression of human β2-adrenoceptors in mice exposes coupling to both Gs and Gi proteins. Br. J. Pharmacol. 2003;138:1361–1369. - PMC - PubMed

[9] KILTS J.D., AKAZAWA T., RICHARDSON M.D., KWATRA M.M. Age increases cardiac Gαi2 expression, resulting in enhanced coupling to G protein-coupled receptors. J. Biol. Chem. 2002;277:31257–31262. - PubMed

[10] KILTS J.D., AKAZAWA T., RICHARDSON M.D., KWATRA M.M. Age increases cardiac Gαi2 expression, resulting in enhanced coupling to G protein-coupled receptors. J. Biol. Chem. 2002;277:31257–31262. - PubMed

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The ups and downs of Gs- to Gi-protein switching

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The ups and downs of Gs- to Gi-protein switching

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