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. 2003 Aug 12;61(3):365-8.
doi: 10.1212/01.wnl.0000076487.28227.6e.

Dysplasia: a common finding in intractable pediatric temporal lobe epilepsy

B E Porter  1 , A R Judkins, R R Clancy, A Duhaime, D J Dlugos, J A Golden
Affiliations

Dysplasia: a common finding in intractable pediatric temporal lobe epilepsy

B E Porter et al. Neurology. .

Abstract

Background: Risk factors for temporal lobe epilepsy (TLE) include history of CNS infection, family history of epilepsy, and history of febrile convulsions (FC). Pre-existing cortical dysplasia (CD) may also predispose to refractory TLE, independent of other risk factors for epilepsy.

Methods: The authors reviewed the neuropathologic features of surgical tissue from temporal lobectomies of 33 pediatric patients with refractory TLE, with and without a history of epilepsy risk factors.

Results: CD was found in 64% (21/33) of all patients with refractory TLE, including 73% (11/15) patients with a history of FC, 66% (2/3) patients with CNS infections, and 83% (5/6) patients with a family history of epilepsy. Disrupted cortical lamination, dystrophic and maloriented neurons, and balloon cells characterized the CD found in the temporal neocortex.

Conclusion: CD was seen in 21 of 33 surgical specimens from children with refractory TLE, including those with and without other epilepsy risk factors.

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