Review
doi: 10.1016/s0959-4388(03)00101-6.
Lessons from peppers and peppermint: the molecular logic of thermosensation
Affiliations
- PMID: 12965298
- DOI: 10.1016/s0959-4388(03)00101-6
Item in Clipboard
Review
Lessons from peppers and peppermint: the molecular logic of thermosensation
Curr Opin Neurobiol.
2003 Aug.
Abstract
Sensory neurons report a wide range of temperatures, from noxious heat to noxious cold. Natural products that elicit psychophysical sensations of hot or cold, such as capsaicin or menthol, were instrumental in the discovery of thermal detectors belonging to the transient receptor potential (TRP) family of cation channels. Studies are now beginning to reveal how these channels contribute to thermosensation and how chemical signaling pathways, such as those activated by tissue injury, alter thermal sensitivity through TRP channel modulation. Analysis of TRP channel expression among sensory neurons is also providing insight into how thermal stimuli are encoded by the peripheral nervous system.
Similar articles
-
Oral thermosensing by murine trigeminal neurons: modulation by capsaicin, menthol and mustard oil.J Physiol. 2019 Apr;597(7):2045-2061. doi: 10.1113/JP277385. Epub 2019 Feb 10. J Physiol. 2019. PMID: 30656684 Free PMC article.
-
Identification of a cold receptor reveals a general role for TRP channels in thermosensation.Nature. 2002 Mar 7;416(6876):52-8. doi: 10.1038/nature719. Epub 2002 Feb 10. Nature. 2002. PMID: 11882888
-
[TRP channels--sensitive for heat and cold, capsaicin and menthol].Lakartidningen. 2002 May 16;99(20):2302-3. Lakartidningen. 2002. PMID: 12082951 Swedish. No abstract available.
-
How cold is it? TRPM8 and TRPA1 in the molecular logic of cold sensation.Mol Pain. 2005 Apr 22;1:16. doi: 10.1186/1744-8069-1-16. Mol Pain. 2005. PMID: 15847696 Free PMC article. Review.
-
Molecular and cellular mechanisms of trigeminal chemosensation.Ann N Y Acad Sci. 2009 Jul;1170:184-9. doi: 10.1111/j.1749-6632.2009.03895.x. Ann N Y Acad Sci. 2009. PMID: 19686135 Free PMC article. Review.
Cited by
-
Design and construction of a two-temperature preference behavioral assay for undergraduate neuroscience laboratories.J Undergrad Neurosci Educ. 2010 Fall;9(1):A51-6. Epub 2010 Oct 15. J Undergrad Neurosci Educ. 2010. PMID: 23494724 Free PMC article.
-
Contribution of TRPM8 channels to cold transduction in primary sensory neurons and peripheral nerve terminals.J Neurosci. 2006 Nov 29;26(48):12512-25. doi: 10.1523/JNEUROSCI.3752-06.2006. J Neurosci. 2006. PMID: 17135413 Free PMC article.
-
From nociception to pain perception: imaging the spinal and supraspinal pathways.J Anat. 2005 Jul;207(1):19-33. doi: 10.1111/j.1469-7580.2005.00428.x. J Anat. 2005. PMID: 16011543 Free PMC article. Review.
-
TRP channels and mice deficient in TRP channels.Pflugers Arch. 2005 Oct;451(1):11-8. doi: 10.1007/s00424-005-1429-z. Epub 2005 Aug 3. Pflugers Arch. 2005. PMID: 16078044 Review.
-
Thermosensitive TRP channel pore turret is part of the temperature activation pathway.Proc Natl Acad Sci U S A. 2010 Apr 13;107(15):7083-8. doi: 10.1073/pnas.1000357107. Epub 2010 Mar 29. Proc Natl Acad Sci U S A. 2010. PMID: 20351268 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
