doi: 10.1016/j.molbrainres.2003.10.027.
Over expression of ATF-3 protects rat hippocampal neurons from in vivo injection of kainic acid
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- PMID: 15135228
- DOI: 10.1016/j.molbrainres.2003.10.027
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Over expression of ATF-3 protects rat hippocampal neurons from in vivo injection of kainic acid
Brain Res Mol Brain Res.
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Abstract
ATF-3 is a member of the ATF superfamily of transcription factors and is strongly associated with episodes of cellular stress. We demonstrate an association between increases in ATF-3 protein and resistance to exitotoxic cell death in vivo. Intra-hippocampal injection of kainic acid elicited a robust increase in endogenous ATF-3 within kainate-resistant cells of the dentate gyrus, while overexpression of exogenous ATF-3 was found to protect vulnerable CA3 neurons from the same insult. These results suggest a positive contribution to neuronal survival in the context of stress-induced death, and support an anti-apoptotic role for ATF-3 in the brain.
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