Upstream and downstream of mTOR
- PMID: 15314020
- DOI: 10.1101/gad.1212704
Upstream and downstream of mTOR
Abstract
The evolutionarily conserved checkpoint protein kinase, TOR (target of rapamycin), has emerged as a major effector of cell growth and proliferation via the regulation of protein synthesis. Work in the last decade clearly demonstrates that TOR controls protein synthesis through a stunning number of downstream targets. Some of the targets are phosphorylated directly by TOR, but many are phosphorylated indirectly. In this review, we summarize some recent developments in this fast-evolving field. We describe both the upstream components of the signaling pathway(s) that activates mammalian TOR (mTOR) and the downstream targets that affect protein synthesis. We also summarize the roles of mTOR in the control of cell growth and proliferation, as well as its relevance to cancer and synaptic plasticity.
Similar articles
-
Rheb activation of mTOR and S6K1 signaling.Methods Enzymol. 2006;407:542-55. doi: 10.1016/S0076-6879(05)07044-8. Methods Enzymol. 2006. PMID: 16757352
-
When translation meets transformation: the mTOR story.Oncogene. 2006 Oct 16;25(48):6423-35. doi: 10.1038/sj.onc.1209887. Oncogene. 2006. PMID: 17041627 Review.
-
The mammalian target of rapamycin-signaling pathway in regulating metabolism and growth.J Anim Sci. 2008 Apr;86(14 Suppl):E36-50. doi: 10.2527/jas.2007-0567. Epub 2007 Nov 12. J Anim Sci. 2008. PMID: 17998426 Review.
-
Insulin-like growth factor-1 (IGF-1) and leucine activate pig myogenic satellite cells through mammalian target of rapamycin (mTOR) pathway.Mol Reprod Dev. 2008 May;75(5):810-7. doi: 10.1002/mrd.20832. Mol Reprod Dev. 2008. PMID: 18033679
-
Insulin and amino-acid regulation of mTOR signaling and kinase activity through the Rheb GTPase.Oncogene. 2006 Oct 16;25(48):6361-72. doi: 10.1038/sj.onc.1209882. Oncogene. 2006. PMID: 17041622 Review.
Cited by
-
Combinatorial Therapies to Overcome BRAF/MEK Inhibitors Resistance in Melanoma Cells: An in vitro Study.J Exp Pharmacol. 2021 May 24;13:521-535. doi: 10.2147/JEP.S297831. eCollection 2021. J Exp Pharmacol. 2021. PMID: 34079392 Free PMC article.
-
Novel agents in indolent lymphomas.Ther Adv Hematol. 2013 Apr;4(2):133-48. doi: 10.1177/2040620712466865. Ther Adv Hematol. 2013. PMID: 23610620 Free PMC article.
-
Macrophage autophagy in atherosclerosis.Mediators Inflamm. 2013;2013:584715. doi: 10.1155/2013/584715. Epub 2013 Jan 21. Mediators Inflamm. 2013. PMID: 23401644 Free PMC article. Review.
-
Deficiency in either 4E-BP1 or 4E-BP2 augments innate antiviral immune responses.PLoS One. 2014 Dec 22;9(12):e114854. doi: 10.1371/journal.pone.0114854. eCollection 2014. PLoS One. 2014. PMID: 25531441 Free PMC article.
-
Inhibition of Notch uncouples Akt activation from hepatic lipid accumulation by decreasing mTorc1 stability.Nat Med. 2013 Aug;19(8):1054-60. doi: 10.1038/nm.3259. Epub 2013 Jul 7. Nat Med. 2013. PMID: 23832089 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Molecular Biology Databases
Miscellaneous
