Review
doi: 10.1124/mol.105.016071.
Epub 2005 Jun 24.
Can a GDP-liganded G-protein be active?
Affiliations
- PMID: 15980156
- DOI: 10.1124/mol.105.016071
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Review
Can a GDP-liganded G-protein be active?
Mol Pharmacol.
2005 Sep.
Abstract
The replacement of GDP bound to the alpha-subunit of a G-protein by GTP is generally considered a crucial step in the activation of effectors by a G-protein. New data by Uğur et al. (2005) (p. 720) raise the possibility that for the heterotrimeric G-protein Gs, GDP-liganded Gs is able to activate the effector adenylyl cyclase as potently and effectively as when Gs is in its GTP bound form. We summarize here the evidence that GTP is necessary for effector activation by G-proteins and discuss potential implications and limitations of data to the contrary.
Comment on
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Guanine nucleotide exchange-independent activation of Gs protein by beta2-adrenoceptor.Mol Pharmacol. 2005 Sep;68(3):720-8. doi: 10.1124/mol.104.010306. Epub 2005 Jun 2. Mol Pharmacol. 2005. PMID: 15933218
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