Review
doi: 10.1016/j.bbapap.2005.10.002.
Epub 2005 Oct 25.
The role of SMG-1 in nonsense-mediated mRNA decay
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- PMID: 16289965
- DOI: 10.1016/j.bbapap.2005.10.002
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Review
The role of SMG-1 in nonsense-mediated mRNA decay
Biochim Biophys Acta.
.
Abstract
SMG-1, a member of the PIKK (phosphoinositide 3-kinase related kinases) family, plays a critical role in the mRNA quality control system termed nonsense-mediated mRNA decay (NMD). NMD protects the cells from the accumulation of aberrant mRNAs with premature termination codons (PTCs) that encode nonfunctional or potentially harmful truncated proteins. SMG-1 directly phosphorylates Upf1, another key component of NMD, and this phosphorylation occurs upon recognition of PTC on post-spliced mRNA during the initial round of translation. At present, a variety of tools are available that can specifically suppress NMD, and it is possible to examine the contribution of NMD in a variety of physiological and pathological conditions.
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