Review
doi: 10.1016/j.neuron.2006.04.009.
Numbing the senses: role of TRPA1 in mechanical and cold sensation
Affiliations
- PMID: 16630827
- DOI: 10.1016/j.neuron.2006.04.009
Item in Clipboard
Review
Numbing the senses: role of TRPA1 in mechanical and cold sensation
Neuron.
.
Free article
Abstract
In this issue of Neuron, Kwan et al. demonstrate that TRPA1 is critical for the transduction of noxious cold and mechanical stimuli, as well as in mediating the activation of nociceptors by endogenous and natural irritants. Differences between the present report and a previous study indicate that further study is needed to reach a consensus on the role of TRPA1 in the transduction of mechanical and noxious cold stimuli.
Comment on
-
TRPA1 contributes to cold, mechanical, and chemical nociception but is not essential for hair-cell transduction.Neuron. 2006 Apr 20;50(2):277-89. doi: 10.1016/j.neuron.2006.03.042. Neuron. 2006. PMID: 16630838
Similar articles
-
TRPA1 contributes to cold, mechanical, and chemical nociception but is not essential for hair-cell transduction.Neuron. 2006 Apr 20;50(2):277-89. doi: 10.1016/j.neuron.2006.03.042. Neuron. 2006. PMID: 16630838
-
TRPA1 modulates mechanotransduction in cutaneous sensory neurons.J Neurosci. 2009 Apr 15;29(15):4808-19. doi: 10.1523/JNEUROSCI.5380-08.2009. J Neurosci. 2009. PMID: 19369549 Free PMC article.
-
How cold is it? TRPM8 and TRPA1 in the molecular logic of cold sensation.Mol Pain. 2005 Apr 22;1:16. doi: 10.1186/1744-8069-1-16. Mol Pain. 2005. PMID: 15847696 Free PMC article. Review.
-
Roles of transient receptor potential channels in pain.Brain Res Rev. 2009 Apr;60(1):2-23. doi: 10.1016/j.brainresrev.2008.12.018. Epub 2008 Dec 31. Brain Res Rev. 2009. PMID: 19203589 Free PMC article. Review.
-
Role of TRP channels in pain sensation.Adv Exp Med Biol. 2011;704:615-36. doi: 10.1007/978-94-007-0265-3_33. Adv Exp Med Biol. 2011. PMID: 21290319 Review.
Cited by
-
TRPA1 mediates the noxious effects of natural sesquiterpene deterrents.J Biol Chem. 2008 Aug 29;283(35):24136-44. doi: 10.1074/jbc.M710280200. Epub 2008 Jun 11. J Biol Chem. 2008. PMID: 18550530 Free PMC article.
-
Synergistic role of TRPV1 and TRPA1 in pancreatic pain and inflammation.Gastroenterology. 2011 Apr;140(4):1283-1291.e1-2. doi: 10.1053/j.gastro.2010.12.033. Epub 2010 Dec 24. Gastroenterology. 2011. PMID: 21185837 Free PMC article.
-
The role of TRPA1 in muscle pain and mechanical hypersensitivity under inflammatory conditions in rats.Neuroscience. 2015 Dec 3;310:206-15. doi: 10.1016/j.neuroscience.2015.09.042. Epub 2015 Sep 21. Neuroscience. 2015. PMID: 26393428 Free PMC article.
-
Activation of TRPV1 and TRPA1 leads to muscle nociception and mechanical hyperalgesia.Pain. 2009 Aug;144(3):270-277. doi: 10.1016/j.pain.2009.04.021. Epub 2009 May 22. Pain. 2009. PMID: 19464796 Free PMC article.
-
The effect of allyl isothiocyanate on chondrocyte phenotype is matrix stiffness-dependent: Possible involvement of TRPA1 activation.Front Mol Biosci. 2023 Mar 16;10:1112653. doi: 10.3389/fmolb.2023.1112653. eCollection 2023. Front Mol Biosci. 2023. PMID: 37006615 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
