doi: 10.1016/j.febslet.2006.06.092.
Epub 2006 Jul 10.
Inhibition of histone acetyltransferase activity by anacardic acid sensitizes tumor cells to ionizing radiation
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- PMID: 16844118
- DOI: 10.1016/j.febslet.2006.06.092
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Inhibition of histone acetyltransferase activity by anacardic acid sensitizes tumor cells to ionizing radiation
FEBS Lett.
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Free article
Abstract
Histone acetyltransferases (HATs) regulate transcription, chromatin structure and DNA repair. Here, we utilized a novel HAT inhibitor, anacardic acid, to examine the role of HATs in the DNA damage response. Anacardic acid inhibits the Tip60 HAT in vitro, and blocks the Tip60-dependent activation of the ATM and DNA-PKcs protein kinases by DNA damage in vivo. Further, anacardic acid sensitizes human tumor cells to the cytotoxic effects of ionizing radiation. These results demonstrate a central role for HATs such as Tip60 in regulating the DNA damage response. HAT inhibitors provide a novel therapeutic approach for increasing the sensitivity of tumors to radiation therapy.
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