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Case Reports
. 2007 Mar-Apr;17(2):394-7.
doi: 10.1111/j.1525-1438.2006.00766.x.

Discordance of clinical symptoms and electrophysiologic findings in taxane plus platinum-induced neuropathy

Y Pan  1 , M-S Kao
Affiliations
Free article
Case Reports

Discordance of clinical symptoms and electrophysiologic findings in taxane plus platinum-induced neuropathy

Y Pan et al. Int J Gynecol Cancer. 2007 Mar-Apr.
Free article

Abstract

Paclitaxel combined with carboplatin is currently accepted as the first-line treatment for ovarian carcinoma, frequently associated with neuropathy. Due to its frequent association with neuropathy, combination of docetaxel and carboplatin has been suggested as an alternative. A 47-year-old woman developed paresthesia after the first cycle of paclitaxel/carboplatin for ovarian cancer. Her nerve conduction study (NCS) showed only sural neuropathy after completion of six cycles, which returned to normal in 6 months. She had fewer neuropathy symptoms when treatment was changed to docetaxel/carboplatin for recurrent cancer. NCS revealed generalized sensory neuropathy following docetaxel/carboplatin treatment, which normalized after 12 months. Our observation indicated that there is a disparity between clinical symptoms and electrophysiologic examination in taxane-induced neuropathy. Although docetaxel was tolerated well by the patient, evidence of generalized sensory neuropathy was present in NCS.

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